COASY (NM_001042530) Human Untagged Clone

CAT#: SC321977

COASY (untagged)-Human CoA synthase (COASY), nuclear gene encoding mitochondrial protein, transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COASY
• Synonyms: DPCK; FLJ35179; NBP; pOV-2; PPAT; UKR1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC321977 CGGACGCGTGGGCGCGGTGGTGCAAGTGGAACCCAAGCCTTGAGGTTTCAGTGAGTAGGG
  GGCCGACGTGAGCTTTAGCGTCCCCCTTTAGCCTCCCTCTTCGATTCCTTGAAGACCCTG
  GTGCAGCTTAGCAAGAGGGCCCAGGATTTTTGGATCCCCAGCCCTGTGACAAGGGTTCCT
  GTCCAGTTTCCCCCTCCCAGGATTTCGACTCAGTTCAGCGAAGTCACCGCCCCGTCTGAG
  AAATGAGGACACCAAGGCTTAGAGCACAGCCCCGAGGCGCCGTCTACCAGGCCCCGTCCC
  CTCCCCCGGCTCCTGTCGGTCAGCACTGAAACCCCGTCCCTGCTCCAGGCCTCCTTCTCT
  GGGGTCCAAGGTCCCATACAGGCCTCTGCCTCGGCCGCAGGCCCTTCAGTCACCGTCGCC
  TCGTCTCCCTGACTGTCCGCAGGCCTGGGCAGCATGGCCGTATTCCGGTCGGGTCTCCTG
  GTGCTGACGACGCCGCTGGCCTCCCTAGCCCCTCGCCTGGCCTCCATCCTGACCTCGGCG
  GCCCGGCTGGTGAATCACACACTCTATGTTCACCTGCAGCCGGGCATGAGCCTGGAGGGC
  CCGGCTCAGCCCCAGTACAGCCCCGTGCAGGCCACGTTTGAGGTTCTTGATTTCATCACG
  CACCTCTATGCTGGCGCCGACGTCCACAGGCACTTGGACGTCAGAATCCTACTGACCAAT
  ATCCGAACCAAGAGCACCTTTCTCCCTCCCCTGCCCACCTCAGTCCAGAATCTCGCCCAC
  CCGCCAGAAGTCGTGTTGACAGATTTCCAGACCCTGGATGGAAGCCAGTACAACCCGGTC
  AAACAGCAGCTAGTGCGTTACGCCACCAGCTGTTACAGCTGTTGTCCGCGACTGGCCTCG
  GTGCTGCTATACTCCGATTATGGGATAGGAGAAGTGCCCGTGGAGCCCCTGGATGTCCCC
  TTACCCTCCACGATCAGGCCAGCTTCCCCCGTGGCCGGGTCTCCAAAGCAGCCGGTGCGT
  GGCTACTACCGTGGCGCTGTCGGTGGCACGTTTGACCGCCTGCACAACGCCCACAAGGTG
  TTGCTCAGTGTCGCGTGCATCCTGGCCCAGGAGCAGCTTGTGGTGGGAGTAGCAGACAAA
  GATCTGTTGAAGAGCAAGTTGCTCCCTGAGCTGCTCCAACCTTATACAGAACGTGTGGAA
  CATCTGAGTGAATTCCTGGTGGACATCAAGCCCTCCTTGACTTTTGATGTCATCCCCCTG
  CTGGACCCCTATGGGCCCGCTGGCTCTGACCCCTCCCTGGAGTTCCTGGTGGTCAGCGAG
  GAGACCTATCGTGGGGGGATGGCCATCAACCGCTTCCGCCTTGAGAATGACCTGGAGGAA
  CTTGCTTTGTACCAGATCCAGCTGCTGAAGGACCTCAGACATACGGAGAATGAAGAGGAC
  AAAGTCAGCTCCTCCAGCTTCCGCCAGCGAATGTTGGGGAACCTGCTTCGGCCTCCATAT
  GAAAGGCCAGAGCTCCCCACATGTCTCTATGTAATTGGGCTGACTGGCATCAGTGGCTCT
  GGGAAGAGCTCAATAGCTCAGCGACTGAAGGGCCTGGGGGCGTTTGTCATTGACAGTGAC
  CACCTGGGTCATCGGGCCTATGCCCCAGGTGGCCCTGCCTACCAGCCTGTGGTGGAGGCC
  TTTGGAACAGATATTCTCCATAAAGATGGCATCATCAACAGGAAGGTCCTAGGCAGCCGG
  GTGTTTGGGAATAAGAAGCAGCTGAAGATACTCACGGACATTATGTGGCCAATTATCGCA
  AAGCTGGCCCGAGAGGAGATGGATCGGGCTGTGGCTGAGGGAAAGCGTGTGTGTGTGATT
  GATGCCGCTGTGTTGCTTGAAGCCGGCTGGCAGAACCTGGTCCATGAGGTGTGGACTGCT
  GTCATCCCAGAGACTGAGGCTGTAAGACGCATTGTGGAGAGGGATGGCCTCAGTGAAGCC
  GCGGCTCAAAGCCGGCTGCAGAGCCAGATGAGCGGGCAGCAGCTTGTGGAACAGAGCCAC
  GTGGTGCTCAGCACCTTGTGGGAGCCGCATATCACCCAACGCCAGGTGGAGAAAGCCTGG
  GCCCTCTTGCAGAAGCGCATTCCCAAGACTCATCAGGCCCTCGACTGAAAAGTTCTCAGT
  GGGGCCAGACTGGCTCCTGGAGCTGACAAGCGACCCCGTGGTGAGGAGAAATGGGGGCCT
  TGATGCTCACCCTGGTTCAGGCCCAGAGGTCCAAGCTATACTGTGCAGGACATGGCCAGG
  CCTGGTGGACACAGGAAGCCTACCCAACACGCTGGTATTTGGCCAACACTGAGGATGTGG
  TTCATGGGGGAGCAGTCCCCTCCCCACTCTTGCCCATGGGTGACTCTTACCCACAGCTGA
  CTAGGGCCAGCGCAAATACTGGAACCTGTAACAGAATTAAAGGTGAATGTTCTGAAAAAA
  AAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC321977 unedited
  GGGCGATTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGCGGACGCGTGGGCGCGGTGGTGCAAG
  TGGAACCCAAGCCTTGAGGTTTCAGTGAGTAGGGGGCCGACGTGAGCTTTAGCGTCCCCC
  TTTAGCCTCCCTCTTCGATTCCTTGAAGACCCTGGTGCAGCTTAGCAAGAGGGCCCAGGA
  TTTTTGGATCCCCAGCCCTGTGACAAGGGTTCCTGTCCAGTTTCCCCCTCCCAGGATTTC
  GACTCAGTTCAGCGAAGTCACCGCCCCGTCTGAGAAATGAGGACACCAAGGCTTAGAGCA
  CAGCCCCGAGGCGCCGTCTACCAGGCCCCGTCCCCTCCCCCGGCTCCTGTCGGTCAGCAC
  TGAAACCCCGTCCCTGCTCCAGGCCTCCTTCTCTGGGGTCCAAGGTCCCATACAGGCCTC
  TGCCTCGGCCGCAGGCCCTTCAGTCACCGTCGCCTCGTCTCCCTGACTGTCCGCAGGCCT
  GGGCAGCATGGCCGTATTCCGGTCGGGTCTCCTGGTGCTGACGACGCCGCTGGCCTCCCT
  AGCCCCTCGCCTGGCCTCCATCCTGACCTCGGCGGCCCGGCTGGTGAATCACACACTCTA
  TGTTCACCTGCAGCCGGGCATGAGCCTGGAGGGCCCGGCTCAGCCCCAGTACAGCCCCGT
  GCAGCCACGTTTGAGGTTCTTGATTTCATCACGCACCTCTATGCTGGCGCCGACGTCCAC
  AGGCACTTGGACGTCAGATCCTACTGACCAATTATCCGAACCAGAGCACCTTTCTCCTCC
  CCTGCCCACCCTCAGTCCAGATCTCCGCCCACCCCGCCAGAGTCGTGTTTGAACGGATTC
  CAGACCTGATGAGCCAGTACATCTGTCAACGGCAGCTAATGCGTACGCCACCAGCTGTTT
  ACCAGCTTGTTTGTCCGCGAACTTGGCCTC
• Restriction Sites: Please inquire
• ACCN: NM_001042530
• ORF Size: 1695 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001042530.1, NP_001035995.1
• RefSeq Size: 2417
• RefSeq ORF: 1695
• Locus ID: 80347
• Protein Pathways: Metabolic pathways, Pantothenate and CoA biosynthesis
• Gene Summary: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
  Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a, also known as CoASy alpha).