ASCC1 (NM_015947) Human Untagged Clone

CAT#: SC322320

ASCC1 (untagged)-Human activating signal cointegrator 1 complex subunit 1 (ASCC1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ASCC1
• Synonyms: ASC1p50; CGI-18; RP11-150D20.4
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322320 AGAGAACGCGCTCGCGTAGAGGAATTCCGGGTCCTCCTCCTCGCCCTACCTTGGTTTACC
  TGCAGCCGCCTAGTCCTCTTCTCCTTCTCTTTGATGATTCAGGGCCTCGGCTTCCCTCAC
  GGGCATAATTGGAATATCATTTGGAGAAAGTGTCATGGAAGTTCTGCGTCCACAGCTTAT
  AAGAATTGATGGCCGGAATTACAGGAAGAATCCAGTCCAAGAACAGACCTATCAACATGA
  AGAAGATGAAGAGGACTTCTATCAAGGCTCCATGGAGTGTGCTGATGAGCCCTGTGATGC
  CTACGAGGTGGAGCAGACCCCACAAGGATTCCGGTCTACTTTGAGGGCCCCCAGCTTGCT
  CTATAAGCATATAGTTGGAAAGAGAGGGGACACTAGGAAGAAAATAGAAATGGAGACCAA
  AACTTCTATTAGCATTCCTAAACCTGGACAAGACGGGGAAATTGTAATCACTGGCCAGCA
  TCGAAATGGTGTAATTTCAGCCCGAACACGGATTGATGTTCTTTTGGACACTTTTCGAAG
  AAAGCAGCCCTTCACTCACTTCCTTGCCTTTTTCCTCAATGAAGTTGAGGTTCAGGAAGG
  ATTCCTGAGATTCCAGGAGGAAGTACTGGCGAAGTGCTCCATGGATCATGGGGTTGACAG
  CAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAG
  TGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAA
  TGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATGAATGA
  TGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAG
  GCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAA
  AGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAAGACCC
  CAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAG
  AGAATCATTTGATGGCCGAAATATTTTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCT
  AAAGCTGAATTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAACTACGC
  TTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTGGAAAGCACTAGAAACTAAACA
  TCTTCACCAGGTGCTGAAGAAAAGTGTCTTCGTTTTAATTGCCAAGCAGGGATGTGGACA
  TTTGGATGGTGACTTCCCTGGGTGGTTCCCCATAGATTCACCATTGCCTCTAATGGTGTC
  TACACCCGTCATACTACCAGCTGAGATGGTGGTGGGCATAAGGAGAATTTGTGCCTATAA
  CCCTTAGTGTGTTCTGGTTTTTTTTCTTTTAATTTTTAAATTGTCGTAAAATACTCATAA
  AACATACTGTCTTCACCATTTTTAAGTGCACAGTTCAGTAACGTTAACTGTTAATACATT
  CATAATGCTGTGTGGCCGTCACCGCCGTCCATCTCCATAGGCTTCTCAGCTTGTAAAATG
  GAAACTGTACCCATTAAACAGTAATTCCCACTCCTCCCAGAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322320 unedited
  TGCTACTTTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGT
  CCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGAGAGAACGCGCTCGCGTAGAGGAA
  TTCCGGGTCCTCCTCCTCGCCCTACCTTGGTTTACCTGCAGCCGCCTAGTCCTCTTCTCC
  TTCTCTTTGATGATTCAGGGCCTCGGCTTCCCTCACGGGCATAATTGGAATATCATTTGG
  AGAAAGTGTCATGGAAGTTCTGCGTCCACAGCTTATAAGAATTGATGGCCGGAATTACAG
  GAAGAATCCAGTCCAAGAACAGACCTATCAACATGAAGAAGATGAAGAGGACTTCTATCA
  AGGCTCCATGGAGTGTGCTGATGAGCCCTGTGATGCCTACGAGGTGGAGCAGACCCCACA
  AGGATTCCGGTCTACTTTGAGGGCCCCCAGCTTGCTCTATAAGCATATAGTTGGAAAGAG
  AGGGGACACTAGGAAGAAAATAGAAATGGAGACCAAAACTTCTATTAGCATTCCTAAACC
  TGGACAAGACGGGGAAATTGTAATCACTGGCCAGCATCGAAATGGTGTAATTTCAGCCCG
  AACACGGATTGATGTTCTTTTGGACACTTTTCGAAGAAAGCAGCCCTTCACTCACTTCCT
  TGCCTTTTTCCTCAATGAAGTTGAGGTTCAGGAAGGATTCCTGAGATTCCAGGAGGAAGT
  ACTGGCGAAGTGCTCCATGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAA
  GCTTCATCTAACTATGGGATTGTTGGTGCTTTTGAGTGAGAGAGATCCAGCAGGACTGTG
  AGAATGCTACAGCATGTAAAGAGATCATATGATATTCTGGGGGTAACCCTTAGAGTGGAA
  ATGGCAGAATGAATCATGAATGAGATCTGGCCTGTGGATTTCTTAACGCCAGTTCATTAG
  AAGAATGGCTCACACGGCCTCTACGGAT
• Restriction Sites: Please inquire
• ACCN: NM_015947
• ORF Size: 1074 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015947.2, NP_057031.2
• RefSeq Size: 2090
• RefSeq ORF: 1074
• Locus ID: 51008
• Domains: KH
• Gene Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
  Transcript Variant: This variant (3) differs in both UTRs and has multiple coding region differences compared to variant 1, one of which results in a frameshift. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).