DYRK3 (NM_001004023) Human Untagged Clone

CAT#: SC322604

DYRK3 (untagged)-Human dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (DYRK3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DYRK3
• Synonyms: DYRK5; hYAK3-2; RED; REDK
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322604 GCAGTGTCTGGTCGAGAGTACCCGTGGGAGCGTCGCGCCGCGGAGGCAGCCGTCCCGGCG
  TAGGTGGCGTGGCCGACCGGACCCCCAACTGGCGCCTCTCCCCGCGCGGGGTCCCGAGCT
  AGGAGATGGGAGGCACAGCTCGTGGGCCTGGGCGGAAGGATGCGGGGCCGCCTGGGGCCG
  GGCTCCCGCCCCAGCAGCGGAGTGGTGGAGCCACAGTGTTAAAGAACAGAGAAGTGATCC
  TTAATCATTTAGAATTTTGCCTCCACCATCCACCAGAAAATGAAGTGGAAAGAGAAGTTG
  GGGGATGGTGTCTATGACACCTTCATGATGATAGATGAAACCAAATGTCCCCCCTGTTCA
  AATGTACTCTGCAATCCTTCTGAACCACCTCCACCCAGAAGACTAAATATGACCACTGAG
  CAGTTTACAGGAGATCATACTCAGCACTTTTTGGATGGAGGTGAGATGAAGGTAGAACAG
  CTGTTTCAAGAATTTGGCAACAGAAAATCCAATACTATTCAGTCAGATGGCATCAGTGAC
  TCTGAAAAATGCTCTCCTACTGTTTCTCAGGGTAAAAGTTCAGATTGCTTGAATACAGTA
  AAATCCAACAGTTCATCCAAGGCACCCAAAGTGGTGCCTCTGACTCCAGAACAAGCCCTG
  AAGCAATATAAACACCACCTCACTGCCTATGAGAAACTGGAAATAATTAATTATCCAGAA
  ATTTACTTTGTAGGTCCAAATGCCAAGAAAAGACATGGAGTTATTGGTGGTCCCAATAAT
  GGAGGGTATGATGATGCAGATGGGGCCTATATTCATGTACCTCGAGACCATCTAGCTTAT
  CGATATGAGGTGCTGAAAATTATTGGCAAGGGGAGTTTTGGGCAGGTGGCCAGGGTCTAT
  GATCACAAACTTCGACAGTACGTGGCCCTAAAAATGGTGCGCAATGAGAAGCGCTTTCAT
  CGTCAAGCAGCTGAGGAGATCCGGATTTTGGAGCATCTTAAGAAACAGGATAAAACTGGT
  AGTATGAACGTTATCCACATGCTGGAAAGTTTCACATTCCGGAACCATGTTTGCATGGCC
  TTTGAATTGCTGAGCATAGACCTTTATGAGCTGATTAAAAAAAATAAGTTTCAGGGTTTT
  AGCGTCCAGTTGGTACACAAGTTTGCCCAGTCCATCTTGCAATCTTTGGATGCCCTCCAC
  AAAAATAAGATTATTCACTGCGATCTGAAGCCAGAAAACATTCTCCTGAAACACCACGGG
  CGCAGTTCAACCAAGGTCATTGACTTTGGGTCCAGCTGTTTCGAGTACCAGAAGCTCTAC
  ACATATATCCAGTCTCGGTTCTACAGAGCTCCAGAAATCATCTTAGGAAGCCGCTACAGC
  ACACCAATTGACATATGGAGTTTTGGCTGCATCCTTGCAGAACTTTTAACAGGACAGCCT
  CTCTTCCCTGGAGAGGATGAAGGAGACCAGTTGGCCTGCATGATGGAGCTTCTAGGGATG
  CCACCACCAAAACTTCTGGAGCAATCCAAACGTGCCAAGTACTTTATTAATTCCAAGGGC
  ATACCCCGCTACTGCTCTGTGACTACCCAGGCAGATGGGAGGGTTGTGCTTGTGGGGGGT
  CGCTCACGTAGGGGTAAAAAGCGGGGTCCCCCAGGCAGCAAAGACTGGGGGACAGCACTG
  AAAGGGTGTGATGACTACTTGTTTATAGAGTTCTTGAAAAGGTGTCTTCACTGGGACCCC
  TCTGCCCGCTTGACCCCAGCTCAAGCATTAAGACACCCTTGGATTAGCAAGTCTGTCCCC
  AGACCTCTCACCACCATAGACAAGGTGTCAGGGAAACGGGTAGTTAATCCTGCAAGTGCT
  TTCCAGGGATTGGGTTCTAAGCTGCCTCCAGTTGTTGGAATAGCCAATAAGCTTAAAGCT
  AACTTAATGTCAGAAACCAATGGTAGTATACCCCTATGCAGTGTATTGCCAAAACTGATT
  AGCTAGTGGACAGAGATATGCCCAGAGATGCATATGTGTATATTTTTATGATCTTACAAA
  CCTGCAAATGGAAAAAATGCAAGCCCATTGGTGGATGTTTTTGTTAGAGTAGACTTTTTT
  TAAACAAGACAAAACATTTTTATATGATTATAAAAGAATTCTTCAAGGGCTAATTACCTA
  ACCAGCTTGTATTGGCCATCTGGAATATGCATTAAATGACTTTTTATAGGTCAATGCAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001004023
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001004023.1, NP_001004023.1
• RefSeq Size: 2301 bp
• RefSeq ORF: 1707 bp
• Locus ID: 8444
• Cytogenetics: 1q32.1
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. The resulting isoform (b), also known as the isoform RED-S, contains a shorter and distinct N-terminus compared to isoform a.