Ankyrin brain (ANK2) (NM_001127493) Human Untagged Clone

CAT#: SC323291

ANK2 (untagged)-Human ankyrin 2, neuronal (ANK2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ANK2
• Synonyms: ANK-2; brank-2; LQT4
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001127493, the custom clone sequence may differ by one or more nucleotides
  ATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCA
  GGCAACCTGGACAAAGTTGTGGAATATCTGAAGGGGGGCATAGACATCAATACCTGCAAT
  CAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCACGTGGGGCTGGTGCAG
  GAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTT
  CACATTGCATCTTTGGCTGGACAAGCAGAAGTTGTCAAAGTTCTTGTTAAGGAAGGAGCC
  AATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATGGCTGCCCAAGAGAAT
  CACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAG
  GATGGCTTTACTCCTCTAGCTGTGGCACTCCAGCAAGGACACAACCAGGCGGTGGCCATC
  CTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTGCATATTGCCGCTAGG
  AAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAA
  TCCAAGATGATGGTGAATAGGACAACTGAGAGTGGTTTTACCCCTTTGCACATAGCTGCA
  CATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGAGCTGCTGTGGACTTC
  ACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATG
  GTGAAGCTCTTACTGGATCGAGGCGGTCAGATCGATGCCAAAACTAGGGATGGGTTGACA
  CCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAACTTCTGTTGGAACGG
  GGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAG
  GGAGACCACGTGGAATGTGTGAAGCACCTGTTACAGCACAAGGCACCTGTTGATGATGTC
  ACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGCCACTACCGTGTAACC
  AAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCA
  CTGCACATTGCCTGCAAGAAAAACCGCATCAAAGTCATGGAACTGCTGGTGAAATATGGG
  GCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACATGTGGCTGCCTTCATG
  GGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAAC
  ATTCGTGGTGAGACGGCACTACACATGGCAGCCCGAGCCGGGCAGGTGGAAGTGGTCCGA
  TGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAGGAACAGACACCTTTA
  CATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCT
  CATCCAGATGCGGCCACTACAAATGGGTACACACCACTGCACATCTCTGCCCGGGAGGGC
  CAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCACTCCTTAGCTACCAAG
  AAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTT
  CTCTTGCAACGCCGTGCTGCCGCAGATTCTGCAGGGAAGAACGGCCTTACCCCGCTCCAT
  GTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTGGAGAAGGGTGCTTCC
  CCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAA
  ATGCAGATAGCTTCCACACTCCTGAACTATGGAGCAGAGACAAACATTGTGACAAAGCAA
  GGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGATATGGTTACCTTGCTT
  CTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTT
  GCAGCCCAGGAAGATAAAGTGAATGTTGCTGATATTCTCACCAAGCATGGAGCTGATCAG
  GATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGTCACTATGGAAATGTG
  AAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGC
  TACACGCCTTTGCACCAGGCCGCTCAGCAGGGTCACACGCACATCATCAACGTCCTGCTC
  CAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACTGCCTTGGCGATTGCT
  AAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACC
  ACCACCACCACAACTATTACAGAAAAACACAAACTAAATGTACCTGAGACGATGACTGAG
  GTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGTGATGGGGGAGAATAC
  CTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTG
  GATGGTATGAATTACCTGCGATACAGCTTGGAGGGAGGACGATCTGACAGCCTTCGATCC
  TTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTGAGGGACAGTGCCGTG
  ATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAA
  AGGAATTCTTATCGCCTAAGCTGGGGCACTGAGAACTTAGACAACGTGGCTCTTTCTTCT
  AGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGACAACAGCAGTTTCCTG
  GTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTC
  CGAATCATTATTCCACCTCGGAAATGTACTGCTCCAACGCGAGTCACCTGCCGACTGGTC
  AAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAAGGCCTGGCCAGTCGC
  CTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCT
  CCTCCCCCACTTAATGAGGGAGAAAGTTTGGTCAGCCGCATTCTTCAGCTGGGGCCTCCT
  GGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTTGCGGCCCTTCGAGGA
  AAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTC
  TGTGACTACACTGAAGATGAATTGAATGAAATTCTTAACGGCATGGATGAAGTACTGGAT
  AGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACCCGAGACTTCCCACAG
  TACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGT
  GTACTGAGCAGCACAGTGGTGCCCCAGGTGCAGGCCGTCTTCCCAGAGGGGGCACTCACC
  AAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAGCTGGTTAAGAAGATC
  CTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTC
  CACAAACCAATTACCATGACCATTCCTGTCCCCAAAGCTTCAAGTGATGTCATGTTGAAT
  GGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATAACAGGTGGAACCACC
  CCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTT
  TCCTTTACAACAAACGTGTCTGCCAGGTTCTGGCTGATAGATTGTCGACAGATCCAGGAA
  TCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTACCTTATATGGCCAAA
  TTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATG
  ACTGATGATAAAGTGGATAAGACCCTTGAACAACAAGAAAATTTTGCTGAGGTGGCCAGA
  AGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGATTGTTTCGGCAACTTG
  GTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAAT
  AGACTTCCTCTATTTGTCAAGGTACGCGATACGACTCAGGAACCTTGCGGACGACTATCA
  TTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCTATTTGCAACTTAAAC
  ATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATC
  GATATGACATCAGAAAAAAATCCACAGGATGAGCAGGAACGGATCGAGGAAAGGCTGGCT
  TATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGAGAACTGGATTTCACT
  GAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCAT
  GCACTGTTGAAGTACTGGCTAGAGAGGGATGGGAAACATGCTACAGATACCAACCTCGTT
  GAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATGGAGACCAACACAGAA
  CCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGAT
  CATAGTGAAGGGTTCTCGGTACTTCAAGAGGAGTTATGCACTGCACAGCACAAGCAGAAA
  GAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCTCCTATCGTCTCAGAG
  GAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGAC
  AGCTCAGCAACAGCACTCTTTCCCCAAACTCACAAGGAGCAAGTTCAACAGGATTTCTCA
  GGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAGCAGGAATATTTTGTG
  ACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCC
  AGCAAGACACCTGAGGAAGTTAGCACCCCTGCAGAGGAGGAGAAGCTGTACCTCCAGACC
  CCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCCGAAGAGCCCTCAGAG
  CACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAAC
  CAGCCTGAGACCTGTGAAAGACTCGATGAAGATGCAGCTTTTGAAAAGGGAGACGATATG
  CCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGATGAGCATGGACACACC
  GTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAG
  AAAGAAGAGATTATGGTGCAGGGAATGCCACAGGAACCTGTCAACATCGAGGAAGGGGAT
  GGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACCGAGCAGTCAGAGGAC
  AACAATGAG
  
• Restriction Sites: Please inquire
• ACCN: NM_001127493
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001127493.1, NP_001120965.1
• RefSeq Size: 8082 bp
• RefSeq ORF: 5592 bp
• Locus ID: 287
• Cytogenetics: 4q25-q26
• Protein Families: Druggable Genome
• Gene Summary: 'This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]'
  Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a shorter isoform (3) that has a distinct N-terminus.