Eph receptor A3 (EPHA3) (NM_005233) Human Untagged Clone
CAT#: SC323494
EPHA3 (untagged)-Kinase deficient mutant (K653M) of Human EPH receptor A3 (EPHA3), transcript variant 1
"NM_005233" in other vectors (8)
Product Images
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | EPHA3 |
Synonyms | EK4; ETK; ETK1; HEK; HEK4; TYRO4 |
Vector | pCMV6-XL4 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC323494 sequence for NM_005233 edited (data generated by NextGen Sequencing)
ATGGATTGTCAGCTCTCCATCCTCCTCCTTCTCAGCTGCTCTGTTCTCGACAGCTTCGGG GAACTGATTCCGCAGCCTTCCAATGAAGTCAATCTACTGGATTCAAAAACAATTCAAGGG GAGCTGGGCTGGATCTCTTATCCATCACATGGGTGGGAAGAGATCAGTGGTGTGGATGAA CATTACACACCCATCAGGACTTACCAGGTGTGCAATGTCATGGACCACAGTCAAAACAAT TGGCTGAGAACAAACTGGGTCCCCAGGAACTCAGCTCAGAAGATTTATGTGGAGCTCAAG TTCACTCTACGAGACTGCAATAGCATTCCATTGGTTTTAGGAACTTGCAAGGAGACATTC AACCTGTACTACATGGAGTCTGATGATGATCATGGGGTGAAATTTCGAGAGCATCAGTTT ACAAAGATTGACACCATTGCAGCTGATGAAAGTTTCACTCAAATGGATCTTGGGGACCGT ATTCTGAAGCTCAACACTGAGATTAGAGAAGTAGGTCCTGTCAACAAGAAGGGATTTTAT TTGGCATTTCAAGATGTTGGTGCTTGTGTTGCCTTGGTGTCTGTGAGAGTATACTTCAAA AAGTGCCCATTTACAGTGAAGAATCTGGCTATGTTTCCAGACACGGTACCCATGGACTCC CAGTCCCTGGTGGAGGTTAGAGGGTCTTGTGTCAACAATTCTAAGGAGGAAGATCCTCCA AGGATGTACTGCAGTACAGAAGGCGAATGGCTTGTACCCATTGGCAAGTGTTCCTGCAAT GCTGGCTATGAAGAAAGAGGTTTTATGTGCCAAGCTTGTCGACCAGGTTTCTACAAGGCA TTGGATGGTAATATGAAGTGTGCTAAGTGCCCGCCTCACAGTTCTACTCAGGAAGATGGT TCAATGAACTGCAGGTGTGAGAATAATTACTTCCGGGCAGACAAAGACCCTCCATCCATG GCTTGTACCCGACCTCCATCTTCACCAAGAAATGTTATCTCTAATATAAACGAGACCTCA GTTATCCTGGACTGGAGTTGGCCCCTGGACACAGGAGGCCGGAAAGATGTTACCTTCAAC ATCATATGTAAAAAATGTGGGTGGAATATAAAACAGTGTGAGCCATGCAGCCCAAATGTC CGCTTCCTCCCTCGACAGTTTGGACTCACCAACACCACGGTGACAGTGACAGACCTTCTG GCACATACTAACTACACCTTTGAGATTGATGCCGTTAATGGGGTGTCAGAGCTGAGCTCC CCACCAAGACAGTTTGCTGCGGTCAGCATCACAACTAATCAGGCTGCTCCATCACCTGTC CTGACGATTAAGAAAGATCGGACCTCCAGAAATAGCATCTCTTTGTCCTGGCAAGAACCT GAACATCCTAATGGGATCATATTGGACTACGAGGTCAAATACTATGAAAAGCAGGAACAA GAAACAAGTTATACCATTCTGAGGGCAAGAGGCACAAATGTTACCATCAGTAGCCTCAAG CCTGACACTATATACGTATTCCAAATCCGAGCCCGAACAGCCGCTGGATATGGGACGAAC AGCCGCAAGTTTGAGTTTGAAACTAGTCCAGACTCTTTCTCCATCTCTGGTGAAAGTAGC CAAGTGGTCATGATCGCCATTTCAGCGGCAGTAGCAATTATTCTCCTCACTGTTGTCATC TATGTTTTGATTGGGAGGTTCTGTGGCTATAAGTCAAAACATGGGGCAGATGAAAAAAGA CTTCATTTTGGCAATGGGCATTTAAAACTTCCAGGTCTCAGGACTTATGTTGACCCACAT ACATATGAAGACCCTACCCAAGCTGTTCATGAGTTTGCCAAGGAATTGGATGCCACCAAC ATATCCATTGATAAAGTTGTTGGAGCAGGTGAATTTGGAGAGGTGTGCAGTGGTCGCTTA AAACTTCCTTCAAAAAAAGAGATTTCAGTGGCCATTAAGACCCTGAAAGTTGGCTACACA GAAAAGCAGAGGAGAGACTTCCTGGGAGAAGCAAGCATTATGGGACAGTTTGACCACCCC AATATCATTCGACTGGAAGGAGTTGTTACCAAAAGTAAGCCAGTTATGATTGTCACAGAA TACATGGAGAATGGTTCCTTGGATAGTTTCCTACGTAAACACGATGCCCAGTTTACTGTC ATTCAGCTAGTGGGGATGCTTCGAGGGATAGCATCTGGCATGAAGTACCTGTCAGACATG GGCTATGTTCACCGAGACCTCGCTGCTCGGAACATCTTGATCAACAGTAACTTGGTGTGT AAGGTTTCTGATTTCGGACTTTCGCGTGTCCTGGAGGATGACCCAGAAGCTGCTTATACA ACAAGAGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAG TTCACGTCAGCCAGCGATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTAT GGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAATTAAAGCTGTAGATGAGGGC TATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGC TGGCAGAAAGACAGGAACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAG CTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGCAGCCGCAAGGCCATCAAAC CTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTT AATGGTGTCTGGACAGCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGT GACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGTTGGTGTCACCGTGGTTGGG CCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCA GTTCCCGTGTAA Clone variation with respect to NM_005233.5 >OriGene 5' read for mutant NM_005233 unedited
ACCCCGCCCCGTTGCACCGAGGGCGGTAGGCGTGTCGGAAGGGAGGTCTATATAAGCAGAGCTCGTTAGT GAACCGACATTTTTTTGTAATACCACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGATGGAGATATG CTCCTCTCACTGCCCTCTGCACCCACAACATGGATTGTCAACTTTCCACCCTCCTCCTTCTCAACTGCTC TGCTCTCGACCGGTTCACGGACCTGACCCCGCAACCTTCCGATGAAGGCAAGTTACTGGATTCAACACGA TTCAAGGGGAGCTGGGCTGTATCTCTTATCCATCAAATGGTGGAAGAAGATCAGTGGGGGGGGGGAACAT ACACACCCTTCAGGCCTTCCAGGTGTGCAAGGTCTGGCCAACACCAAACAATTGGCTAAGAACAACCGGG TCCCAGAAACCCCCCTCAAAACATCTGTGGGCCAACGCTCACTCCACAAAAGCGAATCCCTTTCCTTTGG TTTTTAGGAAAC >SC323494 kinase domain raw sequence. By performing BLASTX analysis with this sequence against NCBI refernce protein database, you can confirm the presence of the kinase-deficient mutation
AATGCTGGGACAGTGATTTGGAGAGGTGTGCAGTGGTCGCTTAAAACTTCCTTCAAAAAAAGAGATTTCA GTGGCCATTATGACCCTGAAAGTTGGCTACACAGAAAAGCAGAGGAGAGACTTCCTGGGAGAAGCAAGCA TTATGGGACAGTTTGACCACCCCAATATCATTCGACTGGAAGGAGTTGTTACCAAAAGTAAGCCAGTTAT GATTGTCACAGAATACATGGAGAATGGTTCCTTGGATAGTTTCCT |
Restriction Sites | Please inquire |
ACCN | NM_005233 |
Insert Size | 6000 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548. |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_005233.3, NP_005224.2 |
RefSeq Size | 5837 bp |
RefSeq ORF | 2952 bp |
Locus ID | 2042 |
Cytogenetics | 3p11.1 |
Domains | pkinase, EPH_lbd, TyrKc, SAM, S_TKc, FN3 |
Protein Families | Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane |
Protein Pathways | Axon guidance |
Gene Summary | 'This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]' Transcript Variant: This variant (1) encodes the longer isoform (a). |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC109197 | EPHA3 (untagged)-Human EPH receptor A3 (EPHA3), transcript variant 1 |
USD 540.00 |
|
RC209191 | EPHA3 (Myc-DDK-tagged)-Human EPH receptor A3 (EPHA3), transcript variant 1 |
USD 750.00 |
|
RC600039 | EPHA3 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens EPH receptor A3, transcript variant 1, Signal peptide (1-20) plus EC domain (21-541) |
USD 650.00 |
|
RG209191 | EPHA3 (GFP-tagged) - Human EPH receptor A3 (EPHA3), transcript variant 1 |
USD 830.00 |
|
RC209191L1 | Lenti ORF clone of Human EPH receptor A3 (EPHA3), transcript variant 1, Myc-DDK-tagged |
USD 1,176.00 |
|
RC209191L2 | Lenti ORF clone of Human EPH receptor A3 (EPHA3), transcript variant 1, mGFP tagged |
USD 1,176.00 |
|
RC209191L3 | Lenti ORF clone of Human EPH receptor A3 (EPHA3), transcript variant 1, Myc-DDK-tagged |
USD 950.00 |
|
RC209191L4 | Lenti ORF clone of Human EPH receptor A3 (EPHA3), transcript variant 1, mGFP tagged |
USD 950.00 |
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