NCOA4 (NM_005437) Human Untagged Clone

CAT#: SC323985

NCOA4 (untagged)-Human nuclear receptor coactivator 4 (NCOA4), transcript variant 5

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NCOA4
• Synonyms: ARA70; ELE1; PTC3; RFG
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005437.1 GGTTAGTGTGGGGCCGTGTCTCAGTCCACCCAAGGTCTCCTCGGATCGCCTGGAGAGGCA
  CTCGGACCTGGAGCAGTGAGGAGAATGAATACCTTCCAAGACCAGAGTGGCAGCTCCAGT
  AATAGAGAACCCCTTTTGAGGTGTAGTGATGCACGGAGGGACTTGGAGCTTGCTATTGGT
  GGAGTTCTCCGGGCTGAACAGCAAATTAAAGATAACTTGCGAGAGGTCAAAGCTCAGATT
  CACAGTTGCATAAGCCGTCACCTGGAATGTCTTAGAAGCCGTGAGGTATGGCTGTATGAA
  CAGGTGGACCTTATTTATCAGCTTAAAGAGGAGACACTTCAACAGCAGGCTCAGCAGCTC
  TACTCGTTATTGGGCCAGTTCAATTGTCTTACTCATCAACTGGAGTGTACCCAAAACAAA
  GATCTAGCCAATCAAGTCTCTGTGTGCCTGGAGAGACTGGGCAGTTTGACCCTTAAGCCT
  GAAGATTCAACTGTCCTGCTCTTTGAAGCTGACACAATTACTCTGCGCCAGACCATCACC
  ACATTTGGGTCTCTCAAAACCATTCAAATTCCTGAGCACTTGATGGCTCATGCTAGTTCA
  GCAAATATTGGGCCCTTCCTGGAGAAGAGAGGCTGTATCTCCATGCCAGAGCAGAAGTCA
  GCATCCGGTATTGTAGCTGTCCCTTTCAGCGAATGGCTCCTTGGAAGCAAACCTGCCAGT
  GGTTATCAAGCTCCTTACATACCCAGCACCGACCCCCAGGACTGGCTTACCCAAAAGCAG
  ACCTTGGAGAACAGTCAGACTTCTTCCAGAGCCTGCAATTTCTTCAATAATGTCGGGGGA
  AACCTAAAGGGCTTAGAAAACTGGCTCCTCAAGAGTGAAAAATCAAGTTATCAAAAGTGT
  AACAGCCATTCCACTACTAGTTCTTTCTCCATTGAAATGGAAAAGGTTGGAGATCAAGAG
  CTTCCTGATCAAGATGAGATGGACCTATCAGATTGGCTAGTGACTCCCCAGGAATCCCAT
  AAGCTGCGGAAGCCTGAGAATGGCAGTCGTGAAACCAGTGAGAAGTTTAAGCTCTTATTC
  CAGTCCTATAATGTGAATGATTGGCTTGTCAAGACTGACTCCTGTACCAACTGTCAGGGA
  AACCAGCCCAAAGGTGTGGAGATTGAAAACCTGGGCAATCTGAAGTGCCTGAATGACCAC
  TTGGAGGCCAAGAAACCATTGTCCACCCCCAGCATGGTTACAGAGGATTGGCTTGTCCAG
  AACCATCAGGACCCATGTAAGGTAGAGGAGGTGTGCAGAGCCAATGAGCCCTGCACAAGC
  TTTGCAGAGTGTGTGTGTGATGAGAATTGTGAGAAGGAGGCTCTGTATAAGTGGCTTCTG
  AAGAAAGAAGGAAAGGATAAAAATGGGATGCCTGTGGAACCCAAACCTGAGCCTGAGAAG
  CATAAAGATTCCCTGAATATGTGGCTCTGTCCTAGAAAAGAAGTAATAGAACAAACTAAA
  GCACCAAAGGCAATGACTCCTTCTAGAATTGCTGATTCCTTCCAAGTCATAAAGAACAGC
  CCCTTGTCGGAGTGGCTTATCAGGCCCCCATACAAAGAAGGAAGTCCCAAGGAAGTGCCT
  GGTACTGAAGACAGAGCTGGCAAACAGAAGTTTAAAAGCCCCATGAATACTTCCTGGTGT
  TCCTTTAACACAGCTGACTGGGTCCTGCCAGGAAAGAAGATGGGCAACCTCAGCCAGTTA
  TCTTCTGGAGAAGACAAGTGGCTGCTTCGAAAGAAGGCCCAGGAAGTATTACTTAATTCA
  CCTCTACAGGAGGAACATAACTTCCCCCCAGACCATTATGGCCTCCCTGCAGTTTGTGAT
  CTCTTTGCCTGTATGCAGCTTAAAGTTGATAAAGAGAAGTGGTTATATCGAACTCCTCTA
  CAGATGTGAAGGAATGGACAAGAGTTGAGCAGCCTTTCTGCTGATTATCACACATCATGA
  GCTGAGTGACTGCAGCTTGCCAAATCTTTGTGTTTCTGGGTCTGACCAATTAGTTCTTCT
  CCTGCCTAATTTTGAACTAGTAAAGCAAAGTGAGTCATCAGATTATGAGTTACTGTTTAA
  AAGAAAAATGCTGTTTATTCATGCTGAGGTGATTCAGTTCCCTCCTTCTTACAGAAGTAT
  TTTAATTCACCCCACACTAGAAATGCAGCATCTTTGTGGACGTCTTTTTCACAAGCCTCC
  AAGGCTCCTTAGATTGGGTCGTTACTAAAAGTACATTAAAACACTCTTGTTTATCGAAGT
  ATATTGATGTATTCTAAAGCTAGTAAACTTCCCTAACGTTTAATTGCCCTACAGATGCTT
  CTCTTGCTGTGGGTTTTCTTTTGTTAGTGGTCTGAAATAATTATTTTCCTGTTCTATTAA
  TACATAGTGTATTTTGCACAAAAAAATTAACCTGGTCAATAGTGATTACCAAAATATATA
  TTAATAATCTTGGCAATTTTTGACATTAATTATGAAACATTTTAGCCCACGTTAGTTCTA
  CATTATTCTTCACTTAAACTCAGCTACTGCAAATTTTGTCTTTCTGTAAATGTTATTAAA
  ATATCCAGTGAGCTCTTTAGAAGGACTCAGTATTATTTCAAGACTATTTTTGAGGTAATT
  CTAGCCTTTTAAAATATTCTACAGACCTACGGGGCTTAAAAGAACCCCAGTACCGACTAA
  GCAAATAGGCAAAAGACATGTTGGAAATGTAGTATAGTACTTGAAACAGTCACTATCATA
  GGGATAATTGGTGCATCCTGTGTAAATGGAAGCTGAGCTTGACACCTGGTGCTTTTAAGT
  AGGGATAAAGTCATCCTCTCACTGCAAGCACAGCATACCTGTACCTCCAAAAGTGACGTT
  TTAGTGAACAGGCCGTTTTCAACACTTGTGCCTTGGGGTGTTCATTGAAGCTTTGTGAAA
  ACTACTGATGTTTTCTCAGTCTCCTTAAAGTTACGTCCATGCTTTAAAATGTCTGTGTAG
  GAGAGAAGTGGGGTTTATAATGTTTTCTCTAAGATATCTTTGCTGCTTTCCAGACTTTGA
  AACTATTAAGCTTCTTAACTGCCTCTTACCGGAAATACTTCTGGGGAAACTTCATGGTCC
  CAAAATGTCATTGCCATACAGCTTCACTAGAGTTCTTTGAACCACAGCTGAAAAGAGCTT
  TGTATTATTTTTTAATTCCCTCCCCAGATATCATTTAGGAGTATTATATAAAGGTGGTGG
  GCAAAAACAATGTAAGGAGCCTTTCCAGTTATCTTGAGTTGCAGCTCTGTAGTTTCTTGA
  GGCCAAACACACTGTATTTTACAAGTCAAAATATAATTTACATTAATCACTATGTTAATG
  AGTATGTAAAACATTCTTTTGCATTGATGAATTTTGTATCTGCTTCCATTAAAAGCATAA
  CAGCCAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005437.1 unedited
  GACAACTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGGGTTAGTGTGGGGCCGTGTCTCAGTC
  CACCCAAGGTCTCCTCGGATCGCCTGGAGAGGCACTCGGACCTGGAGCAGTGAGGAGAAT
  GAATACCTTCCAAGACCAGAGTGGCAGCTCCAGTAATAGAGAACCCCTTTTGAGGTGTAG
  TGATGCACGGAGGGACTTGGAGCTTGCTATTGGTGGAGTTCTCCGGGCTGAACAGCAAAT
  TAAAGATAACTTGCGAGAGGTCAAAGCTCAGATTCACAGTTGCATAAGCCGTCACCTGGA
  ATGTCTTAGAAGCCGTGAGGTATGGCTGTATGAACAGGTGGACCTTATTTATCAGCTTAA
  AGAGGAGACACTTCAACAGCAGGCTCAGCAGCTCTACTCGTTATTGGGCCAGTTCAATTG
  TCTTACTCATCAACTGGAGTGTACCCAAAACAAAGATCTAGCCAATCAAGTCTCTGTGTG
  CCTGGAGAGACTGGGCAGTTTGACCCTTAAGCCTGAAGATTCAACTGTCCTGCTCTTTGA
  AGCTGACACAATTACTCTGCGCCAGACCATCACCACATTTGGGTCTCTCAAAACCATTCA
  AATTCCTGAGCACTTGATGGCTCATGCTAGTTCAGCAAATATTGGGCCCTTCCTGAGAGA
  GAGGCTGTATCTCCATGCCAGAGCAGAGGTCAGCATCCGGTAATGTAGCTGTCCCTTTCA
  GCGAATGGCTCCTTGAGCAACCTGCCAGTGTTATCAAGCTCCTACTACCAGCACGACCCA
  GGACTGCTACCCAAAGCAGACTTGCAGAACAGTCAGAACTTCTTCCGGAAGCCTGCAATT
  TCTTCATTATTTGTTCCG
• Restriction Sites: ECoRI-NOT
• ACCN: NM_005437
• ORF Size: 1845 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005437.1, NP_005428.1
• RefSeq Size: 3506
• RefSeq ORF: 1845
• Locus ID: 8031
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Thyroid cancer
• Gene Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
  Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (5) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein.