NADPH oxidase 4 (NOX4) (NM_001143837) Human Untagged Clone

CAT#: SC325193

NOX4 (untagged)-Human NADPH oxidase 4 (NOX4), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NOX4
• Synonyms: KOX; KOX-1; RENOX
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001143837, the custom clone sequence may differ by one or more nucleotides
  ATGAATGTCCTGCTTTTCTGGAAAACCTTCTTGCTGTATAACCAAGGGCCAGAGTATCAC
  TACCTCCACCAGATGTTGGGGCTAGGATTGTGTCTAAGCAGAGCCTCAGCATCTGTTCTT
  AACCTCAACTGCAGCCTTATCCTTTTACCCATGTGCCGAACACTCTTGGCTTACCTCCGA
  GGATCACAGAAGGTTCCAAGCAGGAGAACCAGGAGATTGTTGGATAAAAGCAGAACATTC
  CATATTACCTGTGGTGTTACTATCTGTATTTTCTCAGGCGTGCATGTGGCTGCCCATCTG
  GTGAATGCCCTCAACTTCTCAGTGAATTACAGTGAAGACTTTGTTGAACTGAATGCAGCA
  AGATACCGAGATGAGGATCCTAGAAAACTTCTCTTCACAACTGTTCCTGGCCTGACAGGG
  GTCTGCATGGTGGTGGTGCTATTCCTCATGATCACAGCCTCTACATATGCAATAAGAGTT
  TCTAACTATGATATCTTCTGGTATACTCATAACCTCTTCTTTGTCTTCTACATGCTGCTG
  ACGTTGCATGTTTCAGGAGGGCTGCTGAAGTATCAAACTAATTTAGATACCCACCCTCCC
  GGCTGCATCAGTCTTAACCGAACCAGCTCTCAGAATATTTCCTTACCAGAGTATTTCTCA
  GAACATTTTCATGAACCTTTCCCTGAAGGATTTTCAAAACCGGCAGAGTTTACCCAGCAC
  AAATTTGTGAAGATTTGTATGGAAGAGCCCAGATTCCAAGCTAATTTTCCACAGACTTGG
  CTTTGGATTTCTGGACCTTTGTGCCTGTACTGTGCCGAAAGACTTTACAGGTATATCCGG
  AGCAATAAGCCAGTCACCATCATTTCGGTCATAAGTCATCCCTCAGATGTCATGGAAATC
  CGAATGGTCAAAGAAAATTTTAAAGCAAGACCTGGTCAGTATATTACTCTACATTGTCCC
  AGTGTATCTGCATTAGAAAATCATCCATTTACCCTCACAATGTGTCCAACTGAAACCAAA
  GCAACATTTGGGGTTCATCTTAAAATAGTAGGAGACTGGACAGAACGATTTCGAGATTTA
  CTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTAT
  CCCAAGCTGTATATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAG
  GTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTAACTCCATTTGCATCAATACTCAACACC
  CTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGA
  GATATCCAGTCCTTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGG
  CAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTCAGTCAAACAGATGGGATA
  CAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCT
  CGGTGGAAACTTTTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTT
  TTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAACTGAGTAACCAGAACAAC
  TCATATGGGACAAGATTTGAATACAATAAAGAGTCTTTCAGC
  
• Restriction Sites: Please inquire
• ACCN: NM_001143837
• ORF Size: 1665 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001143837.1, NP_001137309.1
• RefSeq Size: 4615
• RefSeq ORF: 1665
• Locus ID: 50507
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
  Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in a protein (isoform c) with a shorter N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.