Poliovirus Receptor (PVR) (NM_001135769) Human Untagged Clone

CAT#: SC325827

PVR (untagged)-Human poliovirus receptor (PVR), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PVR
• Synonyms: CD155; HVED; Necl-5; NECL5; PVS; TAGE4
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006505 edited
  GAATTCGGCACGAGGGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGG
  AGCGGCCCCCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGG
  CAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
  AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGT
  GCTGTCCTGGCCACCCCCAGGAACCGGGGACGTCGTCGTGCAGGCGCCCACCCAGGTGCC
  CGGCTTCTTGGGCGACTCCGTGACGCTGCCCTGCTACCTACAGGTGCCCAACATGGAGGT
  GACGCATGTGTCACAGCTGACTTGGGCGCGGCATGGTGAATCTGGCAGCATGGCCGTCTT
  CCACCAAACGCAGGGCCCCAGCTATTCGGAGTCCAAACGGCTGGAATTCGTGGCAGCCAG
  ACTGGGCGCGGAGCTGCGGAATGCCTCGCTGAGGATGTTCGGGTTGCGCGTAGAGGATGA
  AGGCAACTACACCTGCCTGTTCGTCACGTTCCCGCAGGGCAGCAGGAGCGTGGATATCTG
  GCTCCGAGTGCTTGCCAAGCCCCAGAACACAGCTGAGGTTCAGAAGGTCCAGCTCACTGG
  AGAGCCAGTGCCCATGGCCCGCTGCGTCTCCACAGGGGGTCGCCCGCCAGCCCAAATCAC
  CTGGCACTCAGACCTGGGCGGGATGCCCAATACGAGCCAGGTGCCAGGGTTCCTGTCTGG
  CACAGTCACTGTCACCAGCCTCTGGATATTGGTGCCCTCAAGCCAGGTGGACGGCAAGAA
  TGTGACCTGCAAGGTGGAGCACGAGAGCTTTGAGAAGCCTCAGCTGCTGACTGTGAACCT
  CACCGTGTACTACCCCCCAGAGGTATCCATCTCTGGCTATGATAACAACTGGTACCTTGG
  CCAGAATGAGGCCACCCTGACCTGCGATGCTCGCAGCAACCCAGAGCCCACAGGCTATAA
  TTGGAGCACGACCATGGGTCCCCTGCCACCCTTTGCTGTGGCCCAGGGCGCCCAGCTCCT
  GATCCGTCCTGTGGACAAACCAATCAACACAACTTTAATCTGCAACGTCACCAATGCCCT
  AGGAGCTCGCCAGGCAGAACTGACCGTCCAGGTCAAAGGTACAGAGCATGCCAGCGCCTC
  AGCTAATGGGCATGTCTCCTATTCAGCTGTGAGCAGAGAGAACAGCTCTTCCCAGGATCC
  ACAGACAGAGGGCACAAGGTGACAGCGTCGGGACTGAGAGGGGAGAGAGACTGGAGCTGG
  CAAGGACGTGGGCCTCCAGAGTTGGACCCGACCCCAATGGATGAAGACCCCCTCCAAAGA
  GACCAGCCTCCCTCCCTGTGCCAGACCTCAAAACGACGGGGGCAGGTGCAAGTTCATAGG
  TCTCCAAGACCACCCTCCTTTCATTTGCTAGAAGGACTCACTAGACTCAGGAAAGCTGTT
  AGGCTCACAGTTACAGTTTATTACAGTAAAAGGACAGAGATTAAGATCAGCAAAGGGAGG
  AGGTGCACAGCACACGTTCCACGACAGATGAGGCGACGGCTTCCATCTGCCCTCTCCCAG
  TGGAGCCATATAGGCAGCACCTGATTCTCACAGCAACATGTGACAACATGCAAGAAGTAC
  TGCCAATACTGCCAACCAGAGCAGCTCACTCGAGATCTTTGTGTCCAGAGTTTTTTGTTT
  GTCTTGAGACAGGGTCTGGCTCTGTTGGCAGACTAGAGTACAGTGGTGAGATCACAGTTC
  ATTGCAGCCTTGACTTCTCAACGCCAAGTCATCCTCCCACCTCAGCCTCCTGAGTAGCTA
  TGACTACAGGTATGTGCCACCACGTCTGGCTAATCTTTTTATTATTTGTAAAGTCGAGGT
  TTCCCTGTGTTGCCCAGGCTGGTCTTGAACTCTTGGCTCCAAGTGATACTTCTGCCTTGG
  CCTCCCAAAGTGCTGAATTAAGCAGCTCACCATCCACACGGCTGACCTCATACATCAAGC
  CAATACCGTGTGGCCCAAGACCCCCACCATAAATCACATCATTAGCATGAACCACCCAGA
  GTGGCCCAAGACTCCAAGATCAGCTACCAGGCAGGATATTCCAAGGGCTTAGAGATGAAT
  GCCCAGGAGCTGAGGATAAAGGGCCCGATCTTTCTTTGGGCAAGGTTAAGCCTTTACTGC
  ATAGCAGACCACACAGAAGGGTGTGGGCCACCAGAGAATTTTGGTAAAAATTTGGCCTCT
  GGCCTTGAGCTTCTAAATCTCTGTATCCGTCAGATCTCTGTGGTTACAAGAAACAGCCAC
  TGACCCTGGTCACCAGAGGCTGCAATTCAGGCCGCAAGCAGCTGCCTGGGGGGTGTCCAA
  GGAGCAGAGAAAACTACTAGATGTGAACTTGAAGAAGGTTGTCAGCTGCAGCCACTTTCT
  GCCAGCATCTGCAGCCACTTTCTGCCAGCATCTGCAGCCAGCAAGCTGGGACTGGCAGGA
  AATAACCCACAAAAGAAGCAAATGCAATTTCCAACACAAGGGGGAAGGGATGCAGGGGGA
  GGCAGCGCTGCAGTTGCTCAGGACACGCTCCTATAGGACCAAGATGGATGCGACCCAAGA
  CCCAGGAGGCCCAGCTGCTCAGTGCAACTGACAAGTTAAAAAGGTCTATGATCTTGAGGG
  CAGACAGCAGAATTCCTCTTATAAAGAAAACTGTTTGGGAAAATACGTTGAGGGAGAGAA
  GACCTTGGGCCAAGATGCTAAATGGGAATGCAAAGCTTGAGCTGCTCTGCAAGAGAAAAT
  AAGCAGGACAGAGGATTTGCTCTGGACAGAGATGGAAGAGCCGGGAACAGAGAAGTGTGG
  GGAAGAGATAGGAACCAGCAGGATGGCAGGGGCAAAGGGCTCAAGGGTGAGGAGGCCAGT
  GGGACCCCACAGAGTTGGGGAGATAAAGGAACATTGGTTGCTTTGGTGGCACGTAAGCTC
  CTTGTCTGTCTCCAGCACCCAGAATCTCATTAAAGCTTATTTATTGTACCTCCAAAAAAA
  AAAAAAAAAAACTCGAC
  
• Restriction Sites: Please inquire
• ACCN: NM_001135769
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001135769.1, NP_001129241.1
• RefSeq Size: 5745 bp
• RefSeq ORF: 1095 bp
• Locus ID: 5817
• Cytogenetics: 19q13.31
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• Gene Summary: 'The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]'
  Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.