Rubicon (RUBCN) (NM_001145642) Human Untagged Clone

CAT#: SC326632

KIAA0226 (untagged)-Human KIAA0226 (KIAA0226), transcript variant 1, mRNA

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RUBCN
• Synonyms: KIAA0226; RUBICON; SCAR15
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145642, the custom clone sequence may differ by one or more nucleotides
  ATGCAGAGCATCCTCTATCACGGGCTTATCCGTGACCAGGCGTGCCGCCGCCAGACGGAT
  TACTGGCAGTTCGTGAAAGACATCCGGTGGCTCAGTCCCCACTCAGCCCTTCACGTGGAG
  AAGTTCATCAGCGTGCACGAGAACGACCAGAGCAGTGCTGATGGTGCCAGTGAACGTGCT
  GTTGCCGAGCTGTGGCTGCAGCACAGCCTGCAGTACCACTGCCTCTCAGCCCAGCTCCGG
  CCCCTGCTCGGGGATAGACAGTATATCAGAAAATTCTACACAGATGCTGCCTTCCTGCTA
  AGTGACGCTCATGTCACGGCCATGCTGCAGTGCCTGGAAGCAGTGGAACAGAACAACCCC
  CGCCTCCTGGCTCAGATCGATGCGTCCATGTTTGCCAGAAAGCACGAGAGCCCGCTCCTG
  GTGACAAAGAGCCAGAGCCTGACAGCCCTGCCCAGTTCCACATACACCCCTCCAAACAGC
  TATGCTCAGCATTCCTACTTTGGGTCCTTCTCTAGCCTCCACCAATCCGTGCCCAACAAT
  GGCTCAGAGAGAAGATCTACTTCCTTTCCACTCTCTGGCCCTCCCCGGAAACCTCAAGAA
  AGCAGAGGGCACGTCTCACCAGCAGAGGATCAAACCATCCAAGCCCCCCCAGTTTCAGTC
  TCTGCACTAGCCAGGGATTCCCCTTTGACCCCAAATGAAATGAGCTCCAGTACTCTGACC
  AGCCCCATAGAGGCATCCTGGGTCAGCAGCCAGAATGATTCCCCAGGTGATGCCAGTGAG
  GGGCCTGAGTACCTGGCCATTGGCAACTTGGACCCCCGAGGCCGGACTGCCAGCTGTCAG
  AGTCACAGCAGCAATGCCGAGAGCAGCAGTTCCAATTTGTTCTCCTCCAGCAGCTCCCAG
  AAGCCAGATTCTGCTGCCTCTTCCTTAGGGGACCAGGAAGGAGGTGGGGAGAGCCAGCTG
  TCCAGTGTCCTCCGCAGGTCCAGCTTCTCAGAGGGGCAGACACTCACTGTCACCAGTGGG
  GCAAAGAAAAGCCACATTCGCTCCCATTCGGATACCAGCATTGCCTCCAGGGGAGCTCCA
  GGAGGCCCCAGGAATATCACCATTATAGTTGAAGATCCCATTGCAGAATCCTGCAATGAT
  AAGGCGAAGTTGAGAGGCCCTTTGCCCTACTCTGGTCAAAGCAGTGAAGTCAGCACACCC
  AGCTCTCTGTACATGGAATATGAAGGTGGTCGGTACCTGTGCTCAGGGGAAGGCATGTTC
  CGAAGACCATCAGAAGGACAGTCCCTCATCAGCTACCTCTCTGAGCAAGACTTCGGCAGC
  TGTGCCGACCTGGAAAAGGAGAATGCCCACTTCAGCATCTCAGAGTCCTTAATTGCTGCC
  ATCGAGCTAATGAAGTGCAACATGATGAGCCAGTGCCTAGAGGAGGAGGAAGTGGAAGAG
  GAAGACAGTGATAGAGAGATCCAGGAGCTGAAGCAGAAGATCCGCCTTCGGCGCCAGCAA
  ATCCGCACCAAGAACCTGCTCCCCATGTACCAGGAGGCTGAGCACGGAAGCTTTCGGGTC
  ACCTCCAGCAGCTCCCAGTTCAGCTCACGTGATTCGGCACAGCTCTCTGACTCTGGCTCT
  GCTGATGAGGTTGATGAATTTGAAATCCAAGATGCTGACATCAGAAGGAACACAGCCTCA
  AGCAGCAAATCCTTCGTTTCCTCCCAGTCCTTCTCCCACTGCTTCCTGCACTCCACGTCT
  GCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGCCGCC
  TCGGAGCTGGAGTGGCTTGTCCCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCT
  GACTCACTGCCCATCTCACCGGATGACGGGCAGCACGCTGACATCTACAAGCTGCGGATT
  CGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGTTCAT
  CCAGCCCCAACGAGGAAAATTGCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGC
  ATCCGGACTGACCCTGATTACATCAAGCGACTGCGGTACTGTGAGTACCTGGGCAAGTAC
  TTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCGCAAG
  TGGGACTTCAGCAAGTACTACGTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGG
  AATGATCCTCTCTTCAACGTGCAGGACATAAACAGTGCCCTCTATAGGAAGGTCAAGCTG
  CTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAAGACT
  TGCCGACTGGCCAAGGAGCTTCTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAG
  GACCTCCACCTGTACTCACTGAATGACCTGACTGCGACCAGGAAGGGGGAGCTGGGGCCC
  CGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGCTCTGCCAA
  GCCAAAGGCTTCATCTGTGAGTTCTGTCAGAATGAGGATGACATCATCTTTCCCTTTGAG
  CTCCATAAGTGCCGGACCTGTGAAGAGTGTAAAGCGTGTTACCATAAAGCCTGCTTCAAG
  TCTGGAAGCTGTCCGCGCTGCGAGCGGCTGCAGGCCCGGCGGGAGGCACTGGCCAGGCAG
  AGCCTGGAGTCTTACCTGTCAGACTACGAGGAGGAGCCCGCGGAAGCGCTGGCCCTGGAA
  GCCGCCGTCCTGGAGGCCACC
  
• Restriction Sites: Please inquire
• ACCN: NM_001145642
• ORF Size: 2784 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001145642.2, NP_001139114.1
• RefSeq Size: 6903
• RefSeq ORF: 2784
• Locus ID: 9711
• Gene Summary: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
  Transcript Variant: This variant (1) has an alternate 5' exon, which results in translation initiation from a downstream start codon, compared to variant 2. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2.