DAOA (NM_001161812) Human Untagged Clone

CAT#: SC326698

DAOA (untagged)-Human D-amino acid oxidase activator (DAOA) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DAOA
• Synonyms: LG72; SG72
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001161812, the custom clone sequence may differ by one or more nucleotides
  ATGAGGACGGCTATTTGGAAATGGCACAGAGGCATTTACAGAGATCATTATGTCCTTGGG
  TCTCTTACCTTCCTCAGCCCTATGCAGAGAGCTGGGACTTCTAACCAATGGAACATGGGA
  AAGGTGATGACACTTGACTCCGGTGATGAGGTTACCTTTCACAAGACCTGGCCAACTGAG
  ACCGGATCTCCTTACAGGCTTGAAGAAGTAAGCAGCCATGTTGGAAAAGTCTTCATGGCA
  AGAAACTATGAGTTCCTTGCCTATGAGGCCTCTAAGGACCGCAGGCAGCCTCTAGAACGA
  ATGTGGACCTGCAACTACAACCAGCAAAAAGACCAGTCATGCAACCACAAGGAAATAACT
  TCTACCAAAGCTGAA
  
• Restriction Sites: Please inquire
• ACCN: NM_001161812
• ORF Size: 378 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001161812.1, NP_001155284.1
• RefSeq Size: 924
• RefSeq ORF: 378
• Locus ID: 267012
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (2) has additional segments in the 5' and 3' coding regions, as compared to variant 1, which results in a downstream AUG start codon. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1. CCDS Note: This CCDS ID represents the protein described in PMIDs: 12364586 and 14966479. This transcript is supported by AY170469.2. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 18544534. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein.