DDHD1 (NM_001160148) Human Untagged Clone

CAT#: SC327247

DDHD1 (untagged)-Human DDHD domain containing 1 (DDHD1) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DDHD1
• Synonyms: PA-PLA1; PAPLA1; SPG28
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001160148, the custom clone sequence may differ by one or more nucleotides
  ATGAATTACCCGGGCCGCGGGTCCCCACGGAGCCCCGAGCATAACGGCCGAGGCGGCGGC
  GGCGGCGCCTGGGAGCTGGGCTCAGACGCGAGGCCAGCGTTCGGCGGCGGCGTCTGCTGC
  TTCGAGCACCTGCCCGGCGGGGACCCGGACGACGGCGACGTGCCCCTGGCCCTGCTGCGC
  GGGGAACCCGGGCTGCATTTGGCGCCGGGCACCGACGACCACAACCACCACCTCGCGCTG
  GACCCCTGCCTCAGTGACGAGAACTATGACTTCAGCTCCGCCGAGTCGGGCTCCTCGCTG
  CGCTACTACAGCGAGGGTGAGAGCGGCGGCGGCGGCAGCTCCTTGTCGCTGCACCCGCCG
  CAGCAGCCTCCGCTGGTCCCGACGAACTCGGGGGGCGGCGGCGCGACAGGAGGGTCCCCC
  GGGGAAAGGAAACGTACCCGGCTTGGCGGCCCGGCGGCCCGGCACCGCTATGAGGTAGTG
  ACGGAGCTGGGCCCGGAGGAGGTACGCTGGTTCTACAAGGAGGACAAGAAGACCTGGAAG
  CCCTTCATCGGCTACGACTCGCTCCGCATCGAGCTCGCCTTCCGGACCCTGCTGCAGACC
  ACGGGTGCCCGGCCCCAGGGCGGGGACCGGGACGGCGACCATGTGTGCTCCCCCACGGGC
  CCAGCCTCCAGTTCCGGAGAAGATGACGATGAGGACCGCGCCTGCGGCTTCTGCCAGAGT
  ACGACGGGGCACGAGCCGGAGATGGTGGAGCTTGTGAACATCGAGCCTGTGTGCGTGCGG
  GGCGGCCTCTACGAGGTGGATGTGACCCAAGGAGAGTGCTACCCGGTGTACTGGAACCAG
  GCTGATAAAATACCAGTAATGCGTGGACAGTGGTTTATTGACGGCACTTGGCAGCCTCTA
  GAAGAGGAAGAAAGTAATTTAATTGAGCAAGAACATCTCAATTGTTTTAGGGGCCAGCAG
  ATGCAGGAAAATTTCGATATTGAAGTGTCAAAATCCATAGATGGAAAAGATGCTGTTCAT
  AGTTTCAAGTTGAGTCGAAACCATGTGGACTGGCACAGTGTGGATGAAGTATATCTTTAT
  AGTGATGCAACAACATCTAAAATTGCAAGAACAGTTACCCAAAAACTGGGATTTTCTAAA
  GCATCAAGTAGTGGTACCAGACTTCATAGAGGTTATGTAGAAGAAGCCACATTAGAAGAC
  AAGCCATCACAGACTACCCATATTGTATTTGTTGTGCATGGCATTGGGCAGAAAATGGAC
  CAAGGAAGAATTATCAAAAATACAGCTATGATGAGAGAAGCTGCAAGAAAAATAGAAGAA
  AGGCATTTTTCCAACCATGCAACACATGTTGAATTTCTGCCTGTTGAGTGGCGGTCAAAA
  CTTACTCTTGATGGAGACACTGTTGATTCCATTACTCCTGACAAAGTACGAGGTTTAAGG
  GATATGCTGAACAGCAGTGCAATGGACATAATGTATTATACTAGTCCACTTTATAGAGAT
  GAACTAGTTAAAGGCCTTCAGCAAGAGCTGAATCGATTGTATTCCCTTTTCTGTTCTCGG
  AATCCAGACTTTGAAGAAAAAGGGGGTAAAGTCTCAATAGTATCACATTCCTTGGGATGT
  GTAATTACTTATGACATAATGACTGGCTGGAATCCAGTTCGGCTGTATGAACAGTTGCTG
  CAAAAGGAAGAAGAGTTGCCTGATGAACGATGGATGAGCTATGAAGAACGACATCTTCTT
  GATGAACTCTATATAACTAAACGACGGCTGAAGGAAATAGAAGAACGGCTTCACGGATTG
  AAAGCATCATCTATGACACAAACACCTGCCTTAAAATTTAAGGTTGAGAATTTCTTCTGT
  ATGGGATCCCCATTAGCAGTTTTCTTGGCGTTGCGTGGCATCCGCCCAGGAAATACTGGA
  AGTCAAGACCATATTTTGCCTAGAGAGATTTGTAACCGGTTACTAAATATTTTTCATCCT
  ACAGATCCAGTGGCTTATAGATTAGAACCATTAATACTGAAACACTACAGCAACATTTCA
  CCTGTCCAGATCCACTGGTACAATACTTCAAATCCTTTACCTTATGAACATATGAAGCCA
  AGCTTTCTCAACCCAGCTAAAGAACCTACCTCAGTTTCAGAGAATGAAGGCATTTCAACC
  ATACCAAGCCCTGTGACCTCACCAGTTTTGTCCCGCCGACACTATGGAGAATCTATAACA
  AATATAGGCAAAGCAAGCATATTAGGGGCTGCTAGCATTGGAAAGGGACTTGGAGGAATG
  TTGTTCTCAAGATTTGGACGTTCATCTACAACACAGTCATCTGAAACATCAAAAGACTCA
  ATGGAAGATGAGAAGAAGCCAGTTGCCTCACCTTCTGCTACCACCGTAGGGACACAGACC
  CTTCCACATAGCAGTTCTGGCTTCCTCGATTCTGCATATTTCAGACTTCAAGAATCGTTC
  TTTAATCTCCCACAACTTCTTTTTCCGGAAAATGTAATGCAGAATAAAGATAATGCCCTC
  GTGGAGTTGGATCACAGGATTGATTTTGAACTCAGAGAAGGCCTTGTGGAGAGCCGCTAT
  TGGTCAGCTGTCACGTCGCATACTGCCTATTGGTCATCCTTGGATGTTGCCCTTTTTCTT
  TTAACCTTCATGTATAAACATGAGCACGATGATGATGCAAAACCCAATTTAGATCCAATC
  
• Restriction Sites: Please inquire
• ACCN: NM_001160148
• ORF Size: 2703 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001160148.1, NP_001153620.1
• RefSeq Size: 12969
• RefSeq ORF: 2703
• Locus ID: 80821
• Gene Summary: This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
  Transcript Variant: This variant (3) includes an alternate in-frame coding exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is longer and differs at an amino acid in the C-terminal region compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.