ALDH4A1 (NM_001161504) Human Untagged Clone

CAT#: SC327568

ALDH4A1 (untagged)-Human aldehyde dehydrogenase 4 family member A1 (ALDH4A1) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ALDH4A1
• Synonyms: ALDH4; P5CD; P5CDh
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001161504, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAAGCCATCCCATGCGTGGTGGGGGATGAGGAGGTGTGGACGTCGGACGTGCAGTACCAAGTGTCGC
  CTTTTAACCATGGACATAAGGTGGCCAAGTTCTGTTATGCAGACAAGAGCCTGCTCAACAAAGCCATTGA
  GGCTGCCCTGGCTGCCCGGAAAGAGTGGGACCTGAAGCCTATTGCAGACCGGGCCCAGATCTTCCTGAAG
  GCGGCAGACATGCTGAGTGGGCCGCGCAGGGCTGAGATCCTCGCCAAGACCATGGTGGGACAGGGTAAGA
  CCGTGATCCAAGCGGAGATTGACGCTGCAGCGGAACTCATCGACTTCTTCCGGTTCAATGCCAAGTATGC
  GGTGGAGCTGGAGGGGCAGCAGCCCATCAGCGTGCCCCCGAGCACCAACAGCACGGTGTACCGGGGTCTG
  GAGGGCTTCGTGGCGGCCATCTCGCCCTTTAACTTCACTGCAATCGGCGGCAACCTGGCGGGGGCACCGG
  CCCTGATGGGCAACGTGGTCCTATGGAAGCCCAGTGACACTGCCATGCTGGCCAGCTATGCTGTCTACCG
  CATCCTTCGGGAGGCTGGCCTGCCCCCCAACATCATCCAGTTTGTGCCAGCTGATGGGCCCCTATTTGGG
  GACACTGTCACCAGCTCAGAGCACCTCTGTGGCATCAACTTCACAGGCAGTGTGCCCACCTTCAAACACC
  TGTGGAAGCAGGTGGCCCAGAACCTGGACCGGTTCCACACCTTCCCACGCCTGGCTGGAGAGTGCGGCGG
  AAAGAACTTCCACTTCGTGCACCGCTCGGCCGACGTGGAGAGCGTGGTGAGCGGGACCCTCCGCTCAGCC
  TTCGAGTACGGTGGCCAGAAGTGTTCCGCGTGCTCGCGTCTCTACGTGCCGCACTCGCTGTGGCCGCAGA
  TCAAAGGGCGGCTGCTGGAGGAGCACAGTCGGATCAAAGTGGGCGACCCTGCAGAGGATTTTGGGACCTT
  CTTCTCTGCAGTGATTGATGCCAAGTCCTTTGCCCGTATCAAGAAGTGGCTGGAGCACGCACGCTCCTCA
  CCCAGCCTCACCATCCTGGCCGGGGGCAAGTGTGATGACTCCGTGGGCTACTTTGTGGAGCCCTGCATCG
  TGGAGAGCAAGGACCCTCAGGAGCCCATCATGAAGGAGGAGATCTTCGGGCCTGTACTGTCTGTGTACGT
  CTACCCGGATGACAAGTACAAGGAGACGCTGCAGCTGGTTGACAGCACCACCAGCTATGGCCTCACGGGG
  GCAGTGTTCTCCCAGGATAAGGACGTCGTGCAGGAGGCCACAAAGGTGCTGAGGAATGCTGCCGGCAACT
  TCTACATCAACGACAAGTCCACTGGCTCGATAGTGGGCCAGCAGCCCTTTGGGGGGGCCCGAGCCTCTGG
  AACCAATGACAAGCCAGGGGGCCCACACTACATCCTGCGCTGGACGTCGCCGCAGGTCATCAAGGAGACA
  CATAAGCCCCTGGGGGACTGGAGCTACGCGTACATGCAGTGA
  
  
• Restriction Sites: SgfI-RsrII
• ACCN: NM_001161504
• ORF Size: 1512 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001161504.1, NP_001154976.1
• RefSeq Size: 3259
• RefSeq ORF: 1512
• Locus ID: 8659
• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways
• Gene Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]
  Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant P5CDhL, resulting in a downstream AUG start codon. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.