NRG3 (NM_001165972) Human Untagged Clone

CAT#: SC327633

NRG3 (untagged)-Human neuregulin 3 (NRG3) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NRG3
• Synonyms: HRG3; pro-NRG3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001165972, the custom clone sequence may differ by one or more nucleotides
  ATGAGTGAAGGGGCGGCCGCTGCCTCGCCACCTGGTGCCGCTTCGGCAGCCGCCGCCTCG
  GCCGAGGAGGGCACCGCGGCGGCTGCGGCGGCGGCAGCGGCGGGCGGGGGCCCGGACGGC
  GGCGGCGAAGGGGCGGCCGAGCCCCCCCGGGAGTTACGCTGTAGCGACTGCATCGTGTGG
  AACCGGCAGCAGACGTGGCTGTGCGTGGTACCTCTGTTCATCGGCTTCATCGGCCTGGGG
  CTCAGCCTCATGCTTCTCAAATGGATCGTGGTGGGCTCCGTCAAGGAGTACGTGCCCACC
  GACCTAGTGGACTCCAAGGGGATGGGCCAGGACCCCTTCTTCCTCTCCAAGCCCAGCTCT
  TTCCCCAAGGCCATGGAGACCACCACCACTACCACTTCCACCACGTCCCCCGCCACCCCC
  TCCGCCGGGGGTGCCGCCTCCTCCAGGACGCCCAACCGGATTAGCACTCGCCTGACCACC
  ATCACGCGGGCGCCCACTCGCTTCCCCGGGCACCGGGTGCCCATCCGGGCCAGCCCGCGC
  TCCACCACAGCACGGAACACTGCGGCCCCTGCGACGGTCCCGTCCACCACGGCCCCGTTC
  TTCAGTAGCAGCACGCTGGGCTCCCGACCCCCGGTGCCAGGAACTCCAAGTACCCAGGCA
  ATGCCCTCCTGGCCTACTGCGGCATACGCTACCTCCTCCTACCTTCACGATTCTACTCCC
  TCCTGGACCCTGTCTCCCTTTCAGGATGCTGCCTCCTCTTCTTCCTCTTCTTCCTCCTCC
  GCTACCACCACCACACCAGAAACTAGCACCAGCCCCAAATTTCATACGACGACATATTCC
  ACAGAGCGATCCGAGCACTTCAAACCCTGCCGAGACAAGGACCTTGCATACTGTCTCAAT
  GATGGCGAGTGCTTTGTGATCGAAACCCTGACCGGATCCCATAAACACTGTCGGTGCAAA
  GAAGGCTACCAAGGAGTCCGTTGTGATCAATTTCTGCCGAAAACTGATTCCATCTTATCG
  GATCCAAACCACTTGGGGATTGAATTCATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTG
  CTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTC
  TACTTCAAAAGCAAGAAACAAGCTAAACAAATCCAAGAGCAGCTGAAAGTGCCACAAAAT
  GGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAAG
  AGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAG
  AAAATGATGGAGTCAAGTTTTGTCGGCCCCCAGTCATTCCCTGAGGTCCCTTCTCCTGAC
  AGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCAA
  AGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGG
  CTAGGTGGAATTGTGGGACCAGCATATCAGCAACTCGAAGAATCAAGGATCCCAGACCAG
  GATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCA
  ATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAG
  GACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCATCCCTTCAGTGGGT
  TTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGC
  AAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATA
  GCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCAGATCCGAATTCTG
  ACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCA
  AGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAA
  TTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAG
  
• Restriction Sites: Please inquire
• ACCN: NM_001165972
• ORF Size: 2088 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001165972.1, NP_001159444.1
• RefSeq Size: 3689
• RefSeq ORF: 2088
• Locus ID: 10718
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ErbB signaling pathway
• Gene Summary: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that is one amino acid shorter, compared to isoform 1.