NOS1 (NM_001204213) Human Untagged Clone
CAT#: SC329730
NOS1 (untagged) - Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 3
"NM_001204213" in other vectors (2)
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Other products for "NOS1"
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | NOS1 |
Synonyms | bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS |
Vector | pCMV6 series |
Sequence Data |
>NCBI ORF sequence for NM_001204213, the custom clone sequence may differ by one or more nucleotides
ATGGGCTCCATCATGCATCCTTCTCAGCATGCAAGGAGGCCTGAAGACGTCCGCACAAAAGGACAGCTCT TCCCTCTCGCCAAAGAGTTTATTGATCAATACTATTCATCAATTAAAAGATTTGGCTCCAAAGCCCACAT GGAAAGGCTGGAAGAGGTGAACAAAGAGATCGACACCACTAGCACTTACCAGCTCAAGGACACAGAGCTC ATCTATGGGGCCAAGCACGCCTGGCGGAATGCCTCGCGCTGTGTGGGCAGGATCCAGTGGTCCAAGCTGC AGGTATTCGATGCCCGTGACTGCACCACGGCCCACGGGATGTTCAACTACATCTGTAACCATGTCAAGTA TGCCACCAACAAAGGGAACCTCAGGTCTGCCATCACCATATTCCCCCAGAGGACAGACGGCAAGCACGAC TTCCGAGTCTGGAACTCCCAGCTCATCCGCTACGCTGGCTACAAGCAGCCTGACGGCTCCACCCTGGGGG ACCCAGCCAATGTGCAGTTCACAGAGATATGCATACAGCAGGGCTGGAAACCGCCTAGAGGCCGCTTCGA TGTCCTGCCGCTCCTGCTTCAGGCCAACGGCAATGACCCTGAGCTCTTCCAGATTCCTCCAGAGCTGGTG TTGGAAGTTCCCATCAGGCACCCCAAGTTTGAGTGGTTCAAGGACCTGGGGCTGAAGTGGTACGGCCTCC CCGCCGTGTCCAACATGCTCCTAGAGATTGGCGGCCTGGAGTTCAGCGCCTGTCCCTTCAGTGGCTGGTA CATGGGCACAGAGATTGGTGTCCGCGACTACTGTGACAACTCCCGCTACAATATCCTGGAGGAAGTGGCC AAGAAGATGAACTTAGACATGAGGAAGACGTCCTCCCTGTGGAAGGACCAGGCGCTGGTGGAGATCAATA TCGCGGTTCTCTATAGCTTCCAGAGTGACAAAGTGACCATTGTTGACCATCACTCCGCCACCGAGTCCTT CATTAAGCACATGGAGAATGAGTACCGCTGCCGGGGGGGCTGCCCTGCCGACTGGGTGTGGATCGTGCCC CCCATGTCCGGAAGCATCACCCCTGTGTTCCACCAGGAGATGCTCAACTACCGGCTCACCCCCTCCTTCG AATACCAGCCTGATCCCTGGAACACGCATGTCTGGAAAGGCACCAACGGGACCCCCACAAAGCGGCGAGC CATTGGCTTCAAGAAGCTAGCAGAAGCTGTCAAGTTCTCGGCCAAGCTGATGGGGCAGGCTATGGCCAAG AGGGTGAAAGCGACCATCCTCTATGCCACAGAGACAGGCAAATCGCAAGCTTATGCCAAGACCTTGTGTG AGATCTTCAAACACGCCTTTGATGCCAAGGTGATGTCCATGGAAGAATATGACATTGTGCACCTGGAACA TGAAACTCTGGTCCTTGTGGTCACCAGCACCTTTGGCAATGGAGATCCCCCTGAGAATGGGGAGAAATTC GGCTGTGCTTTGATGGAAATGAGGCACCCCAACTCTGTGCAGGAAGAAAGGAAGAGCTACAAGGTCCGAT TCAACAGCGTCTCCTCCTACTCTGACTCCCAAAAATCATCAGGCGATGGGCCCGACCTCAGAGACAACTT TGAGAGTGCTGGACCCCTGGCCAATGTGAGGTTCTCAGTTTTTGGCCTCGGCTCACGAGCATACCCTCAC TTTTGCGCCTTCGGACACGCTGTGGACACCCTCCTGGAAGAACTGGGAGGGGAGAGGATCCTGAAGATGA GGGAAGGGGATGAGCTCTGTGGGCAGGAAGAGGCTTTCAGGACCTGGGCCAAGAAGGTCTTCAAGGCAGC CTGTGATGTCTTCTGTGTGGGAGATGATGTCAACATTGAAAAGGCCAACAATTCCCTCATCAGCAATGAT CGCAGCTGGAAGAGAAACAAGTTCCGCCTCACCTTTGTGGCCGAAGCTCCAGAACTCACACAAGGTCTAT CCAATGTCCACAAAAAGCGAGTCTCAGCTGCCCGGCTCCTTAGCCGTCAAAACCTCCAGAGCCCTAAATC CAGTCGGTCAACTATCTTCGTGCGTCTCCACACCAACGGGAGCCAGGAGCTGCAGTACCAGCCTGGGGAC CACCTGGGTGTCTTCCCTGGCAACCACGAGGACCTCGTGAATGCCCTGATCGAGCGGCTGGAGGACGCGC CGCCTGTCAACCAGATGGTGAAAGTGGAACTGCTGGAGGAGCGGAACACGGCTTTAGGTGTCATCAGTAA CTGGACAGACGAGCTCCGCCTCCCGCCCTGCACCATCTTCCAGGCCTTCAAGTACTACCTGGACATCACC ACGCCACCAACGCCTCTGCAGCTGCAGCAGTTTGCCTCCCTAGCTACCAGCGAGAAGGAGAAGCAGCGTC TGCTGGTCCTCAGCAAGGGTTTGCAGGAGTACGAGGAATGGAAATGGGGCAAGAACCCCACCATCGTGGA GGTGCTGGAGGAGTTCCCATCTATCCAGATGCCGGCCACCCTGCTCCTGACCCAGCTGTCCCTGCTGCAG CCCCGCTACTATTCCATCAGCTCCTCCCCAGACATGTACCCTGATGAAGTGCACCTCACTGTGGCCATCG TTTCCTACCGCACTCGAGATGGAGAAGGACCAATTCACCACGGCGTATGCTCCTCCTGGCTCAACCGGAT ACAGGCTGACGAACTGGTCCCCTGTTTCGTGAGAGGAGCACCCAGCTTCCACCTGCCCCGGAACCCCCAA GTCCCCTGCATCCTCGTTGGACCAGGCACCGGCATTGCCCCTTTCCGAAGCTTCTGGCAACAGCGGCAAT TTGATATCCAACACAAAGGAATGAACCCCTGCCCCATGGTCCTGGTCTTCGGGTGCCGGCAATCCAAGAT AGATCATATCTACAGGGAAGAGACCCTGCAGGCCAAGAACAAGGGGGTCTTCAGAGAGCTGTACACGGCT TACTCCCGGGAGCCAGACAAACCAAAGAAGTACGTGCAGGACATCCTGCAGGAGCAGCTGGCGGAGTCTG TGTACCGAGCCCTGAAGGAGCAAGGGGGCCACATATACGTCTGTGGGGACGTCACCATGGCTGCTGATGT CCTCAAAGCCATCCAGCGCATCATGACCCAGCAGGGGAAGCTCTCGGCAGAGGACGCCGGCGTATTCATC AGCCGGATGAGGGATGACAACCGATACCATGAGGATATTTTTGGAGTCACCCTGCGAACGTACGAAGTGA CCAACCGCCTTAGATCTGAGTCCATTGCCTTCATTGAAGAGAGCAAAAAAGACACCGATGAGGTTTTCAG CTCCTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001204213 |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001204213.1, NP_001191142.1 |
RefSeq Size | 10781 bp |
RefSeq ORF | 3297 bp |
Locus ID | 4842 |
Cytogenetics | 12q24.22 |
Protein Families | Druggable Genome |
Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Arginine and proline metabolism, Calcium signaling pathway, Long-term depression, Metabolic pathways, Pathways in cancer, Small cell lung cancer |
Gene Summary | 'The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]' Transcript Variant: This variant (3, also known as TnNOS) contains 2 unique alternate exons (Tex 1 and Tex 2) at the 5' end compared to variant 1, resulting in translation initiation from a downstream AUG, and an isoform (isoform 3, also known as nNOSgamma) with a shorter N-terminus compared to isoform 1. This variant is specifically expressed in the testis, and the encoded isoform has catalytic activity (PMID:9111048). Variants 3 and 4 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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