MRVI1 (NM_001206881) Human Untagged Clone

CAT#: SC331698

MRVI1 (untagged) - Homo sapiens murine retrovirus integration site 1 homolog (MRVI1), transcript variant 6

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MRVI1
• Synonyms: IRAG; JAW1L
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001206881, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCTGAACAGCCCTCAGCCTGGCCCCGTGGAGAGCGAGCTGGGGAAGCAGCTCTTGAAAACGGGCT
  GGGAGGGCAGCCCTCTGCCGAGAAGTCCAACCCAGGATGCGGCAGGAGTGGGTCCCCCAGCCTCCCAGGG
  GAGAGGCCCAGCTGGAGAGCCGATGGGGCCCGAGGCTGGCTCCAAAGCTGAGCTTCCACCCACTGTGTCC
  CGGCCCCCGCTGCTGCGAGGGCTCTCCTGGGACAGTGGCCCTGAAGAACCTGGCCCCCGGCTGCAGAAAG
  TGCTTGCCAAGCTGCCACTGGCAGAGGAAGAAAAGCGTTTTGCAGGCAAGGCCGGCGGCAAGCTGGCCAA
  GGCCCCTGGTCTCAAAGACTTTCAGATACAAGTGCAGCCCGTGCGGATGCAGAAACTGACCAAGCTCCGA
  GAGGAGCACATCCTGATGAGAAATCAGAACTTAGTGGGGCTCAAGCTTCCAGACCTTAGTGAAGCAGCTG
  AGCAGGAAAAAGGGCTTCCTTCTGAACTCTCCCCAGCTATTGAGGAAGAAGAGTCAAAGAGTGGCTTAGA
  TGTCATGCCTAATATTTCTGATGTGCTGCTGCGCAAACTGCGGGTCCACAGGAGTCTCCCTGGAAGTGCC
  CCTCCACTCACTGAAAAGGAAGTTGAGAACGTGTTTGTGCAACTGTCCTTGGCCTTTAGAAATGACAGCT
  ACACTCTGGAATCTAGAATTAACCAGGCTGAAAGGGAACGCAACCTGACAGAGGAGAACACTGAGAAAGA
  ACTGGAAAACTTCAAAGCTTCCATTACGTCCTCAGCTTCACTCTGGCACCACTGTGAGCACCGGGAAACC
  TACCAGAAGTTGCTGGAGGACATCGCTGTCCTGCACCGCCTGGCTGCCCGCCTCTCCAGCCGAGCTGAGG
  TGGTAGGCGCCGTCCGCCAGGAAAAGCGCATGTCGAAAGCAACGGAAGTGATGATGCAGTATGTGGAGAA
  TCTAAAGAGGACGTATGAGAAGGACCATGCGGAGCTCATGGAGTTTAAAAAGCTTGCAAATCAGAATTCA
  AGCCGCAGCTGTGGCCCCTCTGAAGATGGGGTCCCTCGCACGGCACGGTCCATGTCCCTCACGCTGGGAA
  AGAATATGCCTCGCCGGAGGGTCAGCGTTGCTGTGGTTCCTAAGTTTAATGCCCTGAATCTGCCTGGCCA
  AACTCCCAGCTCATCATCCATTCCCTCCTTACCAGCCTTGTCGGAATCACCCAATGGGAAAGGCAGCCTA
  CCTGTCACTTCAGCACTGCCTGCACTTTTGGAAAATGGAAAGACAAATGGGGACCCAGATTGTGAAGCCT
  CTGCTCCTGCGCTGACCCTGAGCTGCCTGGAGGAGCTTAGTCAGGAGACCAAGGCCAGGATGGAGGAAGA
  AGCCTACAGCAAGGGATTCCAAGAAGGTCTAAAGAAGACCAAAGAACTTCAAGACCTGAAGGAGGAGGAG
  GAAGAACAGAAGAGTGAGAGTCCTGAGGAACCTGAAGAGGTAGAAGAAACTGAGGAAGAGGAAAAGGGCC
  CAAGAAGCAGCAAACTTGAAGAATTGGTCCATTTCTTACAAGTCATGTATCCCAAACTGTGTCAGCACTG
  GCAAGTGATCTGGATGATGGCTGCAGTGATGCTGGTCTTGACTGTTGTGCTGGGGCTCTACAATTCCTAT
  AACTCTTGTGCAGAGCAGGCTGATGGGCCCCTTGGAAGATCCACTTGCTCGGCAGCCCAGAGGGACTCCT
  GGTGGAGCTCAGGACTCCAGCATGAGCAGCCTACAGAGCAGTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001206881
• ORF Size: 1794 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001206881.1, NP_001193810.1
• RefSeq Size: 6165
• RefSeq ORF: 1794
• Locus ID: 10335
• Protein Families: Transmembrane
• Protein Pathways: Vascular smooth muscle contraction
• Gene Summary: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
  Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 6 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream AUG start codon compared to CCDS44539.1. It is supported by the mRNA AK127209.1, which lacks the exon containing the alternative non-AUG (CUG) start codon described in PMID:10321731.