D2HGDH (NM_001287249) Human Untagged Clone

CAT#: SC335794

D2HGDH (untagged) - Human D-2-hydroxyglutarate dehydrogenase (D2HGDH), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: D2HGDH
• Synonyms: D2HGD
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001287249, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGTGGGTGGCAGCGTCCCCGTCTTTGACGAGATCATCCTCTCCACTGCCCGCATGAACCGGGTCCTCA
  GCTTCCACAGCGTGTCTGGAATTCTGGTTTGCCAGGCGGGCTGCGTCCTGGAGGAGCTGAGCCGGTATGT
  GGAGGAACGGGACTTCATCATGCCGCTGGACTTAGGAGCCAAGGGCAGCTGCCACATCGGGGGAAACGTG
  GCAACCAACGCTGGAGGCCTGCGGTTTCTTCGATATGGCTCACTGCATGGGACTGTCCTGGGCCTGGAAG
  TGGTGCTGGCCGACGGCACTGTCCTGGACTGCCTGACCTCCCTGAGGAAGGACAACACGGGCTATGACCT
  GAAGCAGCTGTTCATCGGGTCGGAGGGCACTTTGGGGATCATCACCACGGTGTCCATCTTGTGTCCACCC
  AAGCCCAGGGCTGTGAACGTGGCTTTCCTCGGCTGCCCAGGCTTTGCTGAGGTTCTGCAGACCTTCAGCA
  CCTGCAAGGGGATGCTGGGTGAGATCCTGTCTGCATTCGAGTTCATGGATGCTGTGTGCATGCAGCTGGT
  CGGGCGCCATCTCCACCTGGCCAGCCCGGTGCAAGAGAGTCCGTTTTACGTCCTCATCGAGACTTCAGGC
  TCCAACGCAGGCCATGACGCTGAGAAGCTGGGCCACTTCCTGGAGCACGCGCTGGGCTCCGGCCTGGTGA
  CCGATGGGACCATGGCCACCGACCAGAGGAAAGTCAAGATGCTGTGGGCCCTGAGGGAAAGGATCACAGA
  GGCGCTGAGCCGGGATGGCTACGTGTACAAGTACGACCTCTCCCTCCCTGTGGAGCGGCTCTACGACATC
  GTGACTGACCTGCGCGCCCGCCTCGGCCCGCACGCCAAGCACGTGGTGGGCTATGGCCACCTTGGAGATG
  GTAACCTGCACCTCAATGTGACGGCGGAGGCCTTCAGCCCCTCGCTCCTGGCTGCCCTGGAGCCCCACGT
  GTACGAGTGGACGGCCGGGCAGCAGGGCAGCGTCAGCGCGGAGCACGGAGTGGGCTTCAGGAAGAGGGAC
  GTCCTGGGCTACAGCAAGCCACCGGGGGCCCTGCAGCTCATGCAGCAGCTCAAGGCCCTGCTGGACCCCA
  AGGGCATCCTCAACCCCTACAAGACGCTGCCCAGCCAGGCCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001287249
• ORF Size: 1164 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001287249.1, NP_001274178.1
• RefSeq Size: 2276
• RefSeq ORF: 1164
• Locus ID: 728294
• Gene Summary: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.