RPC62 (POLR3C) (NM_001303456) Human Untagged Clone

CAT#: SC336737

POLR3C (untagged) - Human polymerase (RNA) III (DNA directed) polypeptide C (62kD) (POLR3C), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: POLR3C
• Synonyms: RPC3; RPC62
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001303456, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTGGATGGACGAAATAGCTCTCAGACTCCCCAGTACAATGACTCAAGCAGAAATTAAGCTCTGTTCTT
  TGTTGCTGCAAGAGCATTTTGGAGAGATTGTAGAAAAAATTGGAGTCCATCTGATAAGAACCGGCAGCCA
  GCCACTAAGAGTAATTGCCCATGACACAGGAACATCACTGGATCAGGTGAAGAAAGCCCTGTGTGTCCTC
  GTCCAACATAACCTGGTGAGTTATCAAGTGCACAAACGTGGTGTGGTGGAGTATGAAGCCCAGTGCAGCC
  GGGTATTGCGAATGCTTAGATATCCCCGGTACATCTATACTACCAAAACTCTGTACAGTGACACTGGAGA
  GCTGATTGTTGAGGAGCTTCTGTTGAACGGCAAACTGACAATGTCAGCTGTTGTGAAGAAAGTGGCAGAC
  CGGCTCACAGAGACCATGGAGGATGGCAAGACCATGGACTATGCTGAAGTATCAAACACATTTGTGCGAC
  TGGCAGACACACACTTTGTACAACGCTGCCCTTCGGTACCTACCACTGAGAATTCAGACCCTGGGCCACC
  ACCACCTGCCCCCACACTTGTCATTAATGAAAAGGACATGTACCTGGTTCCTAAACTCAGCTTGATAGGG
  AAAGGTAAAAGGAGGAGATCATCTGATGAAGATGCTGCTGGGGAGCCCAAGGCCAAGAGACCAAAATATA
  CTACAGATAACAAGGAGCCCATTCCAGATGATGGGATTTATTGGCAGGCCAACCTTGACAGATTCCACCA
  ACACTTCCGTGACCAAGCCATTGTGAGCGCAGTTGCTAACAGGATGGACCAGACAAGCAGCGAGATTGTG
  CGAACCATGCTCCGAATGAGTGAGATTACCACTTCCTCTAGTGCTCCCTTCACCCAGCCATTGTCTTCCA
  ATGAGATCTTCAGATCCCTACCTGTTGGCTATAACATCTCTAAGCAAGTTCTTGATCAGTATCTCACTCT
  GCTGGCAGATGATCCACTAGAGTTTGTTGGAAAGTCTGGCGACAGTGGTGGAGGAATGTATGTCATCAAC
  CTCCATAAGGCATTAGCATCCCTAGCCACAGCCACTCTGGAGTCCGTCGTACAGGAGAGATTTGGGTCTC
  GCTGTGCTAGAATATTCCGTCTAGTTTTGCAGAAGAAACACATAGAGCAGAAGCAAGTGGAAGACTTTGC
  AATGATTCCTGCAAAGGAGGCAAAGGATATGCTATATAAGATGCTCTCAGAAAATTTCATGTCACTCCAG
  GAAATTCCCAAAACACCAGACCATGCCCCATCCAGGACCTTCTATTTATATACTGTGAACATCCTGTCAG
  CTGCCCGAATGTTGTTGCACAGGTGCTACAAGAGCATAGCCAACTTGATAGAAAGGAGGCAATTTGAAAC
  CAAAGAGAATAAGCGTCTACTAGAAAAATCTCAGAGGGTAGAAGCCATCATTGCATCTATGCAGGCTACT
  GGTGCAGAGGAAGCACAGTTACAAGAAATAGAGGAGATGATCACAGCTCCTGAACGTCAGCAGCTAGAGA
  CCCTGAAACGTAATGTCAACAAGTTGGATGCCAGTGAGATCCAGGTGGACGAAACCATCTTCCTGCTGGA
  GTCTTACATTGAGTGCACCATGAAGAGACAGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001303456
• ORF Size: 1644 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001303456.1, NP_001290385.1
• RefSeq Size: 3722
• RefSeq ORF: 1644
• Locus ID: 10623
• Protein Families: Transcription Factors
• Protein Pathways: Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase
• Gene Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628). [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an upstream start codon compared to variant 1. It encodes isoform 2 which has a longer and distinct N-terminus compared to isoform 1.