ITGA8 (NM_001291494) Human Untagged Clone
CAT#: SC337809
ITGA8 (untagged) - Human integrin, alpha 8 (ITGA8), transcript variant 2
"NM_001291494" in other vectors (1)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | ITGA8 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>NCBI ORF sequence for NM_001291494, the custom clone sequence may differ by one or more nucleotides
ATGTCGCCCGGGGCCAGCCGCGGTCCCCGGGGAAGCCAGGCGCCGCTGATCGCGCCCCTCTGCTGCGCCG CGGCCGCGCTGGGGATGTTGCTGTGGTCCCCCGCCTGTCAGGCGTTCAACCTGGACGTGGAAAAGCTCAC AGTGTACAGCGGCCCCAAGGGCAGCTACTTCGGCTACGCCGTGGACTTCCACATACCCGACGCCCGCACA GCGAGTGTCTTGGTGGGGGCGCCCAAAGCCAACACCAGCCAGCCCGATATCGTGGAAGGGGGAGCCGTCT ATTACTGTCCTTGGCCCGCGGAGGGGTCTGCGCAGTGCAGGCAGATACCGTTTGACACCACCAACAACAG AAAGATCAGAGTTAATGGAACCAAAGAACCTATCGAGTTCAAATCCAATCAGTGGTTTGGAGCAACAGTG AAAGCTCACAAAGGAAAAGTTGTGGCCTGTGCTCCTTTATATCACTGGAGAACTCTTAAACCGACACCAG AAAAGGACCCAGTTGGCACCTGCTATGTAGCAATTCAGAACTTCAGCGCCTATGCCGAGTTCTCTCCTTG CCGGAACAGCAATGCTGATCCGGAAGGCCAGGGTTACTGCCAAGCAGGATTTAGTCTGGATTTTTATAAG AATGGAGACCTTATTGTGGGAGGACCTGGGAGTTTCTACTGGCAAGGACAAGTGATCACTGCCAGTGTTG CAGATATCATTGCAAATTACTCATTCAAGGATATCCTCAGGAAACTGGCAGGAGAAAAGCAGACGGAAGT GGCTCCAGCTTCCTATGATGACAGTTACCTTGAATTGGTTGCTGGAATTCCAAGAGGAGCACAGAATTTT GGATATGTTTCCATCATTAACTCTACGGATATGACGTTTATTCAGAATTTCACGGGAGAACAGATGGCAT CTTATTTTGGATATACCGTTGTCGTATCAGATGTTAACAGTGATGGACTGGATGATGTCCTGGTTGGGGC ACCTCTCTTTATGGAACGTGAATTTGAGAGCAACCCCAGAGAAGTAGGGCAAATCTACCTGTATTTGCAA GTGAGCTCTCTCCTCTTCAGAGACCCCCAGATCCTCACTGGCACCGAGACGTTTGGGAGATTCGGTAGTG CTATGGCACACTTAGGAGACCTGAACCAAGATGGATACAATGACATTGCCATCGGAGTGCCTTTTGCAGG CAAGGATCAAAGAGGCAAAGTGCTCATTTATAATGGGAACAAAGATGGCTTAAACACCAAGCCTTCCCAA GTTCTGCAAGGAGTGTGGGCCTCACATGCTGTCCCTTCCGGATTTGGCTTTACTTTAAGAGGAGATTCAG ACATAGACAAGAATGATTACCCAGATTTGATTGTGGGTGCATTTGGAACAGGAAAAGTCGCTGTTTACAG AGCAAGACCGGTTGTGACTGTAGATGCCCAGCTTCTGCTGCACCCAATGATTATCAATCTTGAAAATAAA ACTTGCCAGGTTCCAGACTCTATGACATCTGCTGCCTGCTTTTCTTTAAGAGTATGTGCATCTGTCACAG GCCAGAGCATTGCAAACACAATAGTCTTGATGGCAGAGGTGCAATTAGATTCCCTGAAACAGAAAGGAGC TATTAAACGGACGCTCTTCCTTGATAACCATCAGGCTCATCGCGTCTTCCCTCTTGTGATAAAAAGGCAG AAATCCCACCAGTGCCAGGATTTCATCGTTTACCTTCGAGATGAAACTGAATTCCGAGATAAATTATCTC CAATCAACATTAGTTTGAATTACAGTTTGGACGAATCCACCTTTAAAGAAGGCCTGGAAGTGAAACCAAT ATTGAACTACTACAGAGAAAACATTGTTAGTGAACAGGCTCACATTCTGGTGGACTGTGGAGAAGACAAT CTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAGCATCAGGTAATCATTGGAGATGAAAATC ACCTTATGCTCATAATAAATGCAAGAAATGAAGGGGAAGGAGCATATGAAGCTGAACTCTTTGTAATGAT ACCAGAAGAGGCAGATTATGTTGGAATCGAACGCAACAACAAGGGATTTCGACCACTGAGCTGTGAGTAC AAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACAAATTATT CCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAAT CAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCG CAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAG AGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAGCTGCACAATATTGGACC AAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTAT ATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAA AGCCTGCTGCCTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCT TGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACA AATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAG TCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGT GTCCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATT AAGACATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAA TACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTGACAGAGC CAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCATGA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001291494 |
ORF Size | 3147 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Reference Data | |
RefSeq | NM_001291494.1, NP_001278423.1 |
RefSeq Size | 6937 |
RefSeq ORF | 3147 |
Locus ID | 8516 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton |
Gene Summary | Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014] Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. It encodes a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC239915 | ITGA8 (myc-DDK-tagged) - Human integrin, alpha 8 (ITGA8), transcript variant 2 |
USD 1,100.00 |
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