Npc1 (NM_008720) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211885L4V
- LentiORF®
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Lenti ORF particles, Npc1 (GFP-tagged) - Mouse Niemann Pick type C1 (Npc1), 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | mGFP |
Symbol | Npc1 |
Synonyms | A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_008720 |
ORF Size | 3831 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211885).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_008720.2, NP_032746.2 |
RefSeq Size | 5209 |
RefSeq ORF | 3834 |
Locus ID | 18145 |
Gene Summary | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. [UniProtKB/Swiss-Prot Function] |
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