Tlr9 (NM_031178) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR227011L4V

Lenti ORF particles, Tlr9 (GFP-tagged) - Mouse toll-like receptor 9 (Tlr9), 200ul, >10^7 TU/mL

Product Images

MR227011L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR227011L4V particle to overexpress human Tlr9-mGFP fusion protein.

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  MR227011L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR227011L4V particle to overexpress human Tlr9-mGFP fusion protein.

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Tlr9
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_031178
• ORF Size: 3096 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR227011).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_031178.2, NP_112455.2
• RefSeq Size: 3471 bp
• RefSeq ORF: 3099 bp
• Locus ID: 81897
• UniProt ID: Q9EQU3
• Cytogenetics: 9 F1
• Gene Summary: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:18931679, PubMed:21402738, PubMed:14993594, PubMed:17474149, PubMed:25686612, PubMed:18820679). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed:14993594). Controls lymphocyte response to Helicobacter infection (PubMed:17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).[UniProtKB/Swiss-Prot Function]