HTRA2 (NM_013247) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200183L3V

Lenti ORF particles, HTRA2 (Myc-DDK-tagged)-Human HtrA serine peptidase 2 (HTRA2), nuclear gene encoding mitochondrial protein, transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: HTRA2
• Synonyms: MGCA8; OMI; PARK13; PRSS25
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_013247
• ORF Size: 1374 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200183).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_013247.4
• RefSeq Size: 2550 bp
• RefSeq ORF: 1377 bp
• Locus ID: 27429
• UniProt ID: O43464
• Cytogenetics: 2p13.1
• Domains: Tryp_SPc, PDZ
• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Parkinson's disease
• MW: 48.8 kDa
• Gene Summary: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]