IFITM2 (NM_006435) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC202067L2V
- LentiORF®
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Lenti ORF particles, IFITM2 (mGFP-tagged) - Human interferon induced transmembrane protein 2 (1-8D) (IFITM2), 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | IFITM2 |
Synonyms | 1-8D; DSPA2c |
Vector | pLenti-C-mGFP |
ACCN | NM_006435 |
ORF Size | 396 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC202067).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_006435.1, NP_006426.1 |
RefSeq Size | 738 |
RefSeq ORF | 399 |
Locus ID | 10581 |
Domains | CD225 |
Protein Families | Transmembrane |
MW | 14.6 kDa |
Gene Summary | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. [UniProtKB/Swiss-Prot Function] |
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