TPMT (NM_000367) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC203309L2V

Lenti ORF particles, TPMT (mGFP-tagged) - Human thiopurine S-methyltransferase (TPMT), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: TPMT
• Synonyms: TPMTD
• Vector: pLenti-C-mGFP
• ACCN: NM_000367
• ORF Size: 735 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC203309).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000367.2, NP_000358.1
• RefSeq Size: 3281 bp
• RefSeq ORF: 738 bp
• Locus ID: 7172
• Cytogenetics: 6p22.3
• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - other enzymes
• MW: 28.2 kDa
• Gene Summary: 'This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]'