Caspase 3 (CASP3) (NM_032991) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC204444L1V
- LentiORF®
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Lenti ORF particles, CASP3 (Myc-DDK tagged) - Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta, 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | CASP3 |
Synonyms | CPP32; CPP32B; SCA-1 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_032991 |
ORF Size | 831 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC204444).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_032991.2, NP_116786.1 |
RefSeq Size | 2522 bp |
RefSeq ORF | 834 bp |
Locus ID | 836 |
Cytogenetics | 4q35.1 |
Domains | CASc, ICE_p10, ICE_p20 |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protease |
Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis |
MW | 31.6 kDa |
Gene Summary | 'The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]' |
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