MARCKS (NM_002356) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210277L1V

Lenti ORF particles, MARCKS (Myc-DDK-tagged)-Human myristoylated alanine-rich protein kinase C substrate (MARCKS), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: MARCKS
• Synonyms: 80K-L; MACS; PKCSL; PRKCSL
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_002356
• ORF Size: 996 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210277).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002356.4, NP_002347.4
• RefSeq Size: 2589 bp
• RefSeq ORF: 999 bp
• Locus ID: 4082
• Cytogenetics: 6q21
• Domains: MARCKS
• Protein Families: Druggable Genome
• Protein Pathways: Fc gamma R-mediated phagocytosis
• MW: 31.4 kDa
• Gene Summary: 'The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]'