Securin (PTTG1) (NM_004219) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC211038L3V
- LentiORF®
Lenti ORF particles, PTTG1 (Myc-DDK tagged) - Human pituitary tumor-transforming 1 (PTTG1), 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | PTTG1 |
Synonyms | EAP1; HPTTG; PTTG; TUTR1 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_004219 |
ORF Size | 606 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC211038).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004219.2, NP_004210.1 |
RefSeq Size | 786 |
RefSeq ORF | 609 |
Locus ID | 9232 |
Domains | Securin |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Cell cycle, Oocyte meiosis |
MW | 22 kDa |
Gene Summary | The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
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