ROCK1 (NM_005406) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC211547L3V
- LentiORF®
Lenti ORF particles, ROCK1 (Myc-DDK tagged) - Human Rho-associated, coiled-coil containing protein kinase 1 (ROCK1), 200ul, >10^7 TU/mL
Buy this product and get 50% off on the Lenti RapidTiter kit. Use Code: Rapid50
Product Images
Other products for "ROCK1"
Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | ROCK1 |
Synonyms | P160ROCK; ROCK-I |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_005406 |
ORF Size | 4062 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC211547).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_005406.2, NP_005397.1 |
RefSeq Size | 6650 bp |
RefSeq ORF | 4065 bp |
Locus ID | 6093 |
Cytogenetics | 18q11.1 |
Domains | pkinase, HR1, PH |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway |
MW | 158.6 kDa |
Gene Summary | 'This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]' |
Documents
Product Manuals |
FAQs |
Resources
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.