RAD50 (NM_005732) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC211751L2V

  • LentiORF®

Lenti ORF particles, RAD50 (mGFP-tagged)-Human RAD50 homolog (S. cerevisiae) (RAD50), 200ul, >10^7 TU/mL

SDS

Biosafety Sheet

USD 1,780.00

6 Weeks*

Size
    • 200 ul
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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol RAD50
Synonyms hRad50; NBSLD; RAD502
Vector pLenti-C-mGFP
ACCN NM_005732
ORF Size 3936 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC211751).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_005732.3, NP_005723.2
RefSeq Size 6597
RefSeq ORF 3939
Locus ID 10111
Domains Rad50_zn_hook
Protein Families Druggable Genome
Protein Pathways Homologous recombination, Non-homologous end-joining
MW 154.3 kDa
Gene Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. [provided by RefSeq, Apr 2010]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.