PRAK (MAPKAPK5) (NM_003668) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC216715L2V

  • LentiORF®

Lenti ORF particles, MAPKAPK5 (mGFP-tagged) - Human mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), transcript variant 1, 200ul, >10^7 TU/mL

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USD 820.00

6 Weeks*

Size
    • 200 ul
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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol MAPKAPK5
Synonyms MAPKAP-K5; MK-5; MK5; PRAK
Vector pLenti-C-mGFP
ACCN NM_003668
ORF Size 1413 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC216715).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_003668.2, NP_003659.2
RefSeq Size 2060
RefSeq ORF 1416
Locus ID 8550
Domains pkinase, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase
Protein Pathways MAPK signaling pathway
MW 53.9 kDa
Gene Summary The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

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