BIN1 (NM_139344) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC220585L2V
- LentiORF®
Lenti ORF particles, BIN1 (mGFP-tagged) - Human bridging integrator 1 (BIN1), transcript variant 2, 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | BIN1 |
Synonyms | AMPH2; AMPHL; CNM2; SH3P9 |
Vector | pLenti-C-mGFP |
ACCN | NM_139344 |
ORF Size | 1650 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC220585).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_139344.1, NP_647594.1 |
RefSeq Size | 2508 bp |
RefSeq ORF | 1653 bp |
Locus ID | 274 |
Cytogenetics | 2q14.3 |
MW | 59.8 kDa |
Gene Summary | 'This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]' |
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