Glypican 3 (GPC3) (NM_001164617) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC228491L1V

Lenti ORF particles, GPC3 (Myc-DDK tagged) - Human glypican 3 (GPC3), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC228491L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC228491L1V particle to overexpress human GPC3-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: GPC3
• Synonyms: DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_001164617
• ORF Size: 1809 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC228491).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001164617.1, NP_001158089.1
• RefSeq ORF: 1812 bp
• Locus ID: 2719
• UniProt ID: P51654, Q53H15
• Cytogenetics: Xq26.2
• Protein Families: Druggable Genome
• MW: 68.41 kDa
• Gene Summary: 'Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]'