Human alpha 2 Macroglobulin (A2M) activation kit by CRISPRa

CAT#: GA100002

A2M CRISPRa kit - CRISPR gene activation of human alpha-2-macroglobulin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: A2M
• Locus ID: 2
• Kit Components:

  GA100002G1, alpha 2 Macroglobulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100002G2, alpha 2 Macroglobulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100002G3, alpha 2 Macroglobulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000014, NM_001347423, NM_001347424, NM_001347425
• Synonyms: A2MD; CPAMD5; FWP007; S863-7
• Summary: 'The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]'