Human Acrosin (ACR) activation kit by CRISPRa

CAT#: GA100037

ACR CRISPRa kit - CRISPR gene activation of human acrosin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACR
• Locus ID: 49
• Kit Components:

  GA100037G1, Acrosin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100037G2, Acrosin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100037G3, Acrosin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001097
• Synonyms: acrosin; preproacrosin; proacrosin
• Summary: 'Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]'