Human ACTC1 activation kit by CRISPRa

CAT#: GA100048

ACTC1 CRISPRa kit - CRISPR gene activation of human actin alpha cardiac muscle 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACTC1
• Locus ID: 70
• Kit Components:

  GA100048G1, ACTC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100048G2, ACTC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100048G3, ACTC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005159
• Synonyms: ACTC; ASD5; CMD1R; CMH11; LVNC4
• Summary: 'Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]'