Human ACTG2 activation kit by CRISPRa

CAT#: GA100050

ACTG2 CRISPRa kit - CRISPR gene activation of human actin gamma 2, smooth muscle

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACTG2
• Locus ID: 72
• Kit Components:

  GA100050G1, ACTG2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100050G2, ACTG2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100050G3, ACTG2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199893, NM_001615
• Synonyms: ACT; ACTA3; ACTE; ACTL3; ACTSG; VSCM
• Summary: 'Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]'