Human Activin Receptor Type IIA (ACVR2A) activation kit by CRISPRa

CAT#: GA100058

ACVR2A CRISPRa kit - CRISPR gene activation of human activin A receptor type 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACVR2A
• Locus ID: 92
• Kit Components:

  GA100058G1, Activin Receptor Type IIA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100058G2, Activin Receptor Type IIA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100058G3, Activin Receptor Type IIA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278579, NM_001278580, NM_001616
• Synonyms: ACTRII; ACVR2
• Summary: 'This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]'