Human Alcohol Dehydrogenase (ADH1A) activation kit by CRISPRa

CAT#: GA100084

ADH1A CRISPRa kit - CRISPR gene activation of human alcohol dehydrogenase 1A (class I), alpha polypeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADH1A
• Locus ID: 124
• Kit Components:

  GA100084G1, Alcohol Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100084G2, Alcohol Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100084G3, Alcohol Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000667
• Synonyms: ADH1
• Summary: This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]