Human ADH1B activation kit by CRISPRa

CAT#: GA100085

ADH1B CRISPRa kit - CRISPR gene activation of human alcohol dehydrogenase 1B (class I), beta polypeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADH1B
• Locus ID: 125
• Kit Components:

  GA100085G1, ADH1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100085G2, ADH1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100085G3, ADH1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000668, NM_001286650, NM_001286650.2
• Synonyms: ADH2; HEL-S-117
• Summary: 'The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]'