Human Adrenomedullin (ADM) activation kit by CRISPRa

CAT#: GA100092

ADM CRISPRa kit - CRISPR gene activation of human adrenomedullin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADM
• Locus ID: 133
• Kit Components:

  GA100092G1, Adrenomedullin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100092G2, Adrenomedullin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100092G3, Adrenomedullin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001124
• Synonyms: AM; PAMP
• Summary: 'The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]'