Human alpha 2a Adrenergic Receptor (ADRA2A) activation kit by CRISPRa

CAT#: GA100103

ADRA2A CRISPRa kit - CRISPR gene activation of human adrenoceptor alpha 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADRA2A
• Locus ID: 150
• Kit Components:

  GA100103G1, alpha 2a Adrenergic Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100103G2, alpha 2a Adrenergic Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100103G3, alpha 2a Adrenergic Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000681
• Synonyms: ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
• Summary: 'Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]'