Human GRK2 activation kit by CRISPRa

CAT#: GA100109

GRK2 CRISPRa kit - CRISPR gene activation of human G protein-coupled receptor kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRK2
• Locus ID: 156
• Kit Components:

  GA100109G1, GRK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100109G2, GRK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100109G3, GRK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001619
• Synonyms: ADRBK1; BARK1; BETA-ARK1
• Summary: 'This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]'