Human Jagged1 (JAG1) activation kit by CRISPRa

CAT#: GA100128

JAG1 CRISPRa kit - CRISPR gene activation of human jagged canonical Notch ligand 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: JAG1
• Locus ID: 182
• Kit Components:

  GA100128G1, Jagged1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100128G2, Jagged1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100128G3, Jagged1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000214
• Synonyms: AGS; AHD; AWS; CD339; HJ1; JAGL1
• Summary: 'The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]'