Human Angiotensin II Type 1 Receptor (AGTR1) activation kit by CRISPRa

CAT#: GA100130

AGTR1 CRISPRa kit - CRISPR gene activation of human angiotensin II receptor type 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AGTR1
• Locus ID: 185
• Kit Components:

  GA100130G1, Angiotensin II Type 1 Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100130G2, Angiotensin II Type 1 Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100130G3, Angiotensin II Type 1 Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000685, NM_004835, NM_009585, NM_031850, NM_032049
• Synonyms: AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R
• Summary: 'Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]'