Human AK3L1 (AK4) activation kit by CRISPRa

CAT#: GA100142

AK4 CRISPRa kit - CRISPR gene activation of human adenylate kinase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AK4
• Locus ID: 205
• Kit Components:

  GA100142G1, AK3L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100142G2, AK3L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100142G3, AK3L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005353, NM_001330616, NM_013410, NM_203464
• Synonyms: AK3; AK3L1; AK3L2; AK 4
• Summary: 'This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]'