Human AKT2 activation kit by CRISPRa

CAT#: GA100144

AKT2 CRISPRa kit - CRISPR gene activation of human AKT serine/threonine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AKT2
• Locus ID: 208
• Kit Components:

  GA100144G1, AKT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100144G2, AKT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100144G3, AKT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243027, NM_001243028, NM_001330511, NM_001626
• Synonyms: HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA
• Summary: 'This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]'