Human NUDT2 activation kit by CRISPRa

CAT#: GA100219

NUDT2 CRISPRa kit - CRISPR gene activation of human nudix hydrolase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NUDT2
• Locus ID: 318
• Kit Components:

  GA100219G1, NUDT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100219G2, NUDT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100219G3, NUDT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161, NM_001244390, NM_147172, NM_147173
• Synonyms: APAH1
• Summary: 'This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]'