Human AIRE activation kit by CRISPRa

CAT#: GA100227

AIRE CRISPRa kit - CRISPR gene activation of human autoimmune regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AIRE
• Locus ID: 326
• Kit Components:

  GA100227G1, AIRE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100227G2, AIRE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100227G3, AIRE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000383, NM_000658, NM_000659
• Synonyms: AIRE1; APECED; APS1; APSI; PGA1
• Summary: 'This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]'