Human ATP2A1 activation kit by CRISPRa

CAT#: GA100342

ATP2A1 CRISPRa kit - CRISPR gene activation of human ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP2A1
• Locus ID: 487
• Kit Components:

  GA100342G1, ATP2A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100342G2, ATP2A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100342G3, ATP2A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286075, NM_004320, NM_173201
• Synonyms: ATP2A; SERCA1
• Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]