Human BCL3 activation kit by CRISPRa

CAT#: GA100414

BCL3 CRISPRa kit - CRISPR gene activation of human BCL3 transcription coactivator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL3
• Locus ID: 602
• Kit Components:

  GA100414G1, BCL3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100414G2, BCL3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100414G3, BCL3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005178
• Synonyms: BCL4; D19S37
• Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]