Human BCMA (TNFRSF17) activation kit by CRISPRa

CAT#: GA100418

TNFRSF17 CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 17

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF17
• Locus ID: 608
• Kit Components:

  GA100418G1, BCMA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100418G2, BCMA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100418G3, BCMA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001192
• Synonyms: BCM; BCMA; CD269; TNFRSF13A
• Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]'